{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:20:07Z","timestamp":1777728007948,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"A multidisciplinary translational medicine platform of systemic autoimmune disease","award":["2014MDT01-06"],"award-info":[{"award-number":["2014MDT01-06"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>S100A12 is an emerging inflammatory disease biomarker. Interstitial lung disease (ILD) is a common, severe complication of dermatomyositis (DM). This study was performed to investigate the association between S100A12 and disease activity and prognosis in patients with DM-associated ILD (i.e., DM-ILD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum S100A12 levels were measured using enzyme-linked immunosorbent assays in patients with stable DM-ILD, patients with acute exacerbation of DM-ILD (AE DM-ILD), and healthy controls (HCs). The relationships of serum S100A12 levels with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ferritin, high-resolution computed tomography (HRCT) scores, and pulmonary functions were evaluated by multiple unpaired t-tests and Pearson correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum S100A12 levels were higher in patients with stable DM-ILD and those with AE DM-ILD than in HCs. Serum S100A12 levels in patients with stable DM-ILD and those with AE DM-ILD were positively correlated with CRP, ESR, and ferritin. S100A12 levels were positively correlated with HRCT scores in patients with stable DM-ILD and those with AE DM-ILD, while they were negatively correlated with predicted percentages of forced vital capacity and predicted percentages of carbon monoxide diffusing capacity in those patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings demonstrate the usefulness of serum S100A12 levels for assessing clinical severity and prognosis of DM-ILD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519887841","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:32:11Z","timestamp":1577071931000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease"],"prefix":"10.1177","volume":"48","author":[{"given":"Yueyan","family":"Lou","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Renji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Renji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Renji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Renji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Renji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-713X","authenticated-orcid":false,"given":"Xiaoming","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Renji Hospital South Campus, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"bibr1-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0741"},{"key":"bibr2-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.05.008"},{"key":"bibr3-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/907078"},{"key":"bibr4-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-008-0097-7"},{"key":"bibr5-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.302072"},{"key":"bibr6-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12352"},{"key":"bibr7-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.11.011"},{"key":"bibr8-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201101-0058OC"},{"key":"bibr9-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"bibr10-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"bibr11-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"bibr12-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373041515"},{"key":"bibr13-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1186\/s40348-018-0085-2"},{"key":"bibr14-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00062-0"},{"key":"bibr15-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.00002015"},{"key":"bibr16-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1553488"},{"key":"bibr17-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.12.040"},{"key":"bibr18-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(03)00094-9"},{"key":"bibr19-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0894CI"},{"key":"bibr20-0300060519887841","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140651"},{"key":"bibr21-0300060519887841","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31829fbc38"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519887841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519887841","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519887841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:02Z","timestamp":1777459862000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519887841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,23]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/0300060519887841"],"URL":"https:\/\/doi.org\/10.1177\/0300060519887841","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,23]]},"article-number":"0300060519887841"}}