{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:20:10Z","timestamp":1777728010586,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The Open Research Fund of State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","award":["SKLVD2018KF001"],"award-info":[{"award-number":["SKLVD2018KF001"]}]},{"name":"The Open Research Fund of State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics","award":["SKLVD2018KF002"],"award-info":[{"award-number":["SKLVD2018KF002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the epidemiological features of a school varicella outbreak in Dongguan City, China, to identify the reasons underlying persistent spread, and to assess the effectiveness of the varicella vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified all cases during the outbreak. We described the outbreak epidemic course and examined the influence of the following variables on the outbreak: sleeping in the dormitory, eating in school, taking school transportation, hand-washing habits, morning examinations, and effectiveness of case isolation. Logistic regression was used to estimate the odds ratio and 95% confidence interval (CI) of contracting varicella.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 92 varicella cases were reported, accounting for 5.53% (92\/1663) of all students. Among cases, 64.13% (59\/92) were vaccinated. The outbreak lasted for 93 days and occurred in six generations. Vaccination coverage was between 78.05% and 85.67%. The varicella vaccine was effective in 56.63% of recipients (95% CI: 35.49\u201370.84%). Vaccine effectiveness significantly decreased after 4\u20136 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The varicella vaccine was unable to prevent virus spread even with high vaccination coverage. Delayed and inefficient isolation of cases was the primary cause of the persistent outbreak.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519887847","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T03:33:18Z","timestamp":1574825598000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["A persistent outbreak of varicella in a primary school in Dongguan City, Guangdong Province, China"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-7666","authenticated-orcid":false,"given":"Jian-ming","family":"Zhong","sequence":"first","affiliation":[{"name":"Futian District Center for Disease Control and Prevention, Shenzhen, People\u2019s Republic of China"},{"name":"Guangdong Field Epidemiology Training Program, Guangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Field Epidemiology Training Program, Guangzhou, People\u2019s Republic of China"},{"name":"Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Dongguan Municipal Center for Disease Control and Prevention, Dongguan City, Guangdong Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-ping","family":"Qiu","sequence":"additional","affiliation":[{"name":"Guangdong Field Epidemiology Training Program, Guangzhou, People\u2019s Republic of China"},{"name":"Boluo County Center for Disease Control and Prevention, Huizhou, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Rao","sequence":"additional","affiliation":[{"name":"Dongguan Municipal Center for Disease Control and Prevention, Dongguan City, Guangdong Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-hui","family":"Lu","sequence":"additional","affiliation":[{"name":"Dongguan Municipal Center for Disease Control and Prevention, Dongguan City, Guangdong Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0710-5086","authenticated-orcid":false,"given":"Tianmu","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen City, Fujian Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao-li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dongguan Municipal Center for Disease Control and Prevention, Dongguan City, Guangdong Province, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"bibr1-0300060519887847","doi-asserted-by":"publisher","DOI":"10.1097\/00013542-199310000-00006"},{"key":"bibr2-0300060519887847","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00276-6"},{"key":"bibr3-0300060519887847","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550180045035"},{"key":"bibr4-0300060519887847","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.3.561"},{"key":"bibr5-0300060519887847","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199912000-00004"},{"key":"bibr6-0300060519887847","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.08.004"},{"key":"bibr7-0300060519887847","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.06.065"},{"key":"bibr8-0300060519887847","unstructured":"http:\/\/www.chinacdc.cn\/jkzt\/ymyjz\/ymlbgd\/201301\/t20130116_76066.htm. 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