{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:13:42Z","timestamp":1787872422634,"version":"build-2784847793"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the influence of curcumin on the Notch2\/Hes-1 pathway after pulmonary injury induction via limb ischemia\u2013reperfusion (I\/R).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult male Sprague\u2013Dawley rats were randomly divided into four groups (n\u2009=\u200930 each): sham, I\/R, curcumin post-treatment (I\/R+Cur), and inhibitor (I\/R+DAPT). Hind-limb ischemia was induced for 4 hours, followed by reperfusion for 4 hours. After ischemia, curcumin (200\u2009mg\/kg) or DAPT (0.5\u2009\u00b5m) was injected intraperitoneally in the I\/R+Cur or I\/R+DAPT group, respectively. PaO\n                      <jats:sub>2<\/jats:sub>\n                      was examined after 4 hours of reperfusion. Pathological changes in the lung and the apoptotic index (AI) were examined. Lung malondialdehyde (MDA), tumor necrosis factor (TNF)-\u03b1, and interleukin (IL)-1\u03b2 levels, the wet\/dry (W\/D) ratio, semi-quantitative score of lung injury (SSLI), and Notch2 protein and Hes-1 mRNA expression were also examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the I\/R group, inflammatory changes were observed, AI increased, and MDA, SSLI, W\/D, TNF-\u03b1, IL-1\u03b2, Notch2, and Hes1-mRNA expression increased, while PaO\n                      <jats:sub>2<\/jats:sub>\n                      decreased compared with the Sham group. Pathological changes in the I\/R+Cur group were reversed. All indexes in the I\/R+DAPT and I\/R+Cur group were similar.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Curcumin post-treatment reduced I\/R-induced lung injury in rats. Its mechanism may be related to the inhibition of Notch2\/Hes-1 signaling pathway and the release of inflammatory factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060519892432","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T10:52:18Z","timestamp":1577789538000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Post-treatment curcumin reduced ischemia\u2013reperfusion-induced pulmonary injury via the Notch2\/Hes-1 pathway"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8442-8113","authenticated-orcid":false,"given":"HaiZou","family":"bo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Central Hospital, Shenyang Medical College, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoSun","family":"feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Central Hospital, Shenyang Medical College, Shenyang, Liaoning Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"key":"bibr1-0300060519892432","first-page":"3451","volume":"8","author":"Fan Z","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr2-0300060519892432","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.12.020"},{"key":"bibr3-0300060519892432","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13258"},{"key":"bibr4-0300060519892432","first-page":"841","volume":"17","author":"Sun X","year":"2012","journal-title":"Chinese J Clin Pharmacol Therap"},{"key":"bibr5-0300060519892432","first-page":"17","volume":"19","author":"Zou Haibo","year":"2019","journal-title":"China J Modern Med"},{"key":"bibr6-0300060519892432","first-page":"474","volume":"4","author":"Xiaofeng S","year":"2014","journal-title":"Chi J Anesthesiol"},{"key":"bibr7-0300060519892432","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.04.013"},{"key":"bibr8-0300060519892432","first-page":"457","volume":"17","author":"Oguz A","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"bibr9-0300060519892432","doi-asserted-by":"publisher","DOI":"10.5455\/jihp.20140302054800"},{"key":"bibr10-0300060519892432","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9873-6"},{"key":"bibr11-0300060519892432","unstructured":"Zou H, Sun X. Effect of curcumin-posttreatment during limb ischemia-reperfusion-induced lung injury in rats[J].\n                      J Shenyang Pharmaceut Univ\n                      2019. ISSN: 1006-2858 CN: 21-1349\/R."},{"key":"bibr12-0300060519892432","first-page":"3643","volume":"23","author":"Zou H","year":"2019","journal-title":"Chinese J Tissue Engineer Res"},{"key":"bibr13-0300060519892432","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.11.012"},{"key":"bibr14-0300060519892432","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000668"},{"issue":"14","key":"bibr15-0300060519892432","first-page":"34","volume":"6","author":"Gubernatorova EO","year":"2017","journal-title":"Adv Healthcare Mat"},{"key":"bibr16-0300060519892432","doi-asserted-by":"publisher","DOI":"10.1177\/0748233711430984"},{"key":"bibr17-0300060519892432","doi-asserted-by":"publisher","DOI":"10.1097\/01.EHX.0000444372.52068.e7"},{"key":"bibr18-0300060519892432","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.896217"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519892432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060519892432","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060519892432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:14Z","timestamp":1777459874000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060519892432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,31]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/0300060519892432"],"URL":"https:\/\/doi.org\/10.1177\/0300060519892432","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,31]]},"article-number":"0300060519892432"}}