{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:51:08Z","timestamp":1787107868650,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Jilin Scientific and Technological Development Program","award":["20150101152JC"],"award-info":[{"award-number":["20150101152JC"]}]},{"name":"the Jilin Scientific and Technological Development Program","award":["20170520010JH"],"award-info":[{"award-number":["20170520010JH"]}]},{"name":"the Bethune plan Project of Jilin University","award":["2015410"],"award-info":[{"award-number":["2015410"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81501343"],"award-info":[{"award-number":["81501343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To measure the effect of febuxostat on the serum levels of uric acid (sUA) and the proinflammatory cytokines interleukin (IL)-6, IL-17 and tumour necrosis factor-\u03b1 (TNF-\u03b1) in Chinese Han patients with gout and hyperuricaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, double-blind, placebo-controlled pilot study enrolled patients with gout and hyperuricaemia (sUA \u2265 8 mg\/dl). Patients were randomized to receive either febuxostat 80 mg or placebo once daily for 24 weeks. The serum levels of sUA, IL-6, IL-17 and TNF-\u03b1 were measured at weeks 0 (baseline), 2, 4, 8, 12, 16 and 24. Baseline clinical and demographic characteristics were recorded for all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 156 patients were randomized: placebo group ( n\u2009=\u200978) and febuxostat group ( n\u2009=\u200978). The febuxostat group showed a significantly greater reduction in sUA compared with the placebo group. Serum uric acid concentration was reduced below 8 mg\/dl in 46 of 61 patients (75.4%) by week 24. There were also reductions in the serum levels IL-6, IL-17 and TNF-\u03b1 in the febuxostat group. In the febuxostat group, 10 of 78 patients (12.82%) discontinued treatment due to adverse drug reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Febuxostat reduced the levels of sUA, TNF-\u03b1, IL-6 and IL-17, but there were some side-effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520902950","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T05:33:02Z","timestamp":1588570382000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["The efficacy and tolerability of febuxostat treatment in a cohort of Chinese Han population with history of gout"],"prefix":"10.1177","volume":"48","author":[{"given":"Yuan-Yuan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Rheumatology, First Hospital of Jilin University, Changchun, Jilin Province, China"},{"name":"Outpatient Department of Paediatrics, First Hospital of Jilin University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, First Hospital of Jilin University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Wei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, First Hospital of Jilin University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, First Hospital of Jilin University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-451X","authenticated-orcid":false,"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, First Hospital of Jilin University, Changchun, Jilin Province, China"},{"name":"The Laboratory of Biomedicine, Jilin University of Pharmaceutical Sciences, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"bibr1-0300060520902950","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.07.038"},{"key":"bibr2-0300060520902950","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3474-8"},{"key":"bibr3-0300060520902950","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-016-0386-y"},{"key":"bibr4-0300060520902950","first-page":"983","volume":"20","author":"Borghi C","year":"2016","journal-title":"Eur Rev Med 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