{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:10:50Z","timestamp":1790892650410,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Thyroid dysfunction may play a role in the development of gestational hypertension. However, this relationship remains unclear. This study was performed to evaluate the association between thyroid hormone parameters during early pregnancy and gestational hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women with singleton pregnancies were recruited into this prospective cohort study at 9 to 13 gestational weeks, and their serum thyroid-stimulating hormone, free thyroxine, and free triiodothyronine concentrations were measured using electrochemiluminescence immunoassays. In total, 1226 participants were included in the final analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1226 participants, 81 subsequently developed gestational hypertension (overall incidence of 6.6%). Compared with women with euthyroidism, both pregnant women with hypothyroidism and those with subclinical hypothyroidism had an increased risk of gestational hypertension (adjusted odds ratio [OR], 3.61; 95% confidence interval [CI], 1.52\u20138.57 and OR, 2.24; 95% CI, 1.06\u20134.72, respectively). When the thyroid-stimulating hormone and free thyroxine concentrations were analyzed by quintiles, the women in the highest thyroid-stimulating hormone quintile had a higher risk of gestational hypertension (adjusted OR, 4.22; 95% CI, 1.78\u20139.05) than the women in the middle quintile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that hypothyroidism, subclinical hypothyroidism, and a high thyroid-stimulating hormone concentration during early pregnancy are risk factors for gestational hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520904814","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T02:30:15Z","timestamp":1582079415000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Association between thyroid hormone parameters during early pregnancy and gestational hypertension: a prospective cohort study"],"prefix":"10.1177","volume":"48","author":[{"given":"Hua","family":"Lai","sequence":"first","affiliation":[{"name":"Medical College of Nanchang University, Nanchang, Jiangxi, P.R. China"},{"name":"Department of Gynaecology and Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Yu","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5671-5772","authenticated-orcid":false,"given":"Huai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"bibr1-0300060520904814","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.19378"},{"key":"bibr2-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.06.039"},{"key":"bibr3-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2566"},{"key":"bibr4-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13590"},{"key":"bibr5-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013509"},{"key":"bibr6-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1186161"},{"key":"bibr7-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4233"},{"key":"bibr8-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1904"},{"key":"bibr9-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14290"},{"key":"bibr10-0300060520904814","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.221268"},{"key":"bibr11-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12693"},{"key":"bibr12-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2803"},{"key":"bibr13-0300060520904814","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/01.AOG.0000437382.03963.88","volume":"122","author":"Roberts JM","year":"2013","journal-title":"Obstet Gynecol"},{"key":"bibr14-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2016.6111"},{"key":"bibr15-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0457"},{"key":"bibr16-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000547"},{"key":"bibr17-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.06.031"},{"key":"bibr18-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000152345.99421.22"},{"key":"bibr19-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1105-1"},{"key":"bibr20-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318240de6a"},{"key":"bibr21-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0418"},{"key":"bibr22-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1505"},{"key":"bibr23-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1112"},{"key":"bibr24-0300060520904814","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.120766"},{"key":"bibr25-0300060520904814","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2015.1110126"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520904814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520904814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520904814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:44:45Z","timestamp":1777459485000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520904814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1177\/0300060520904814"],"URL":"https:\/\/doi.org\/10.1177\/0300060520904814","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"article-number":"0300060520904814"}}