{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:48:32Z","timestamp":1777726112682,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study correlations between expression of microRNA-146a (miR-146a) and immunoglobulin and inflammatory cytokines in serum of patients with Guillain\u2013Barr\u00e9 syndrome (GBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-four patients with GBS were selected as the experimental group and 50 healthy individuals as controls. Reverse transcription-PCR was used to detect expression of miR-146a in peripheral blood of all participants. Immunoturbidometric assay was used to detect immunoglobulins (Ig)G, IgA, and IgM in peripheral blood of all participants. The levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor \u03b1 (TNF-\u03b1) were measured by ELISA in peripheral blood. The expression of miR-146a was compared between the two groups and Pearson correlation analysis was used to analyze correlations between miR-146a and immunoglobulin and inflammatory factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Expression of miR-146a was higher in the GBS group than in controls. Expression of IL-6, CRP, TNF-\u03b1, and IgG was significantly higher in the GBS group than in controls. miR-146a was significantly and positively correlated with IL-6, CRP, TNF-\u03b1, and IgG but not with IgA and IgM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The expression profile of miR-146a in patients with GBS differs from that in healthy individuals. Thus, miR-146a may participate in the pathogenesis of GBS by regulating immune and inflammatory responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520904842","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T16:01:41Z","timestamp":1585584101000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Correlations between microRNA-146a and immunoglobulin and inflammatory factors in Guillain\u2013Barr\u00e9 syndrome"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-0369","authenticated-orcid":false,"given":"Pan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, People\u2019s Hospital of Deyang City, DeYang, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The second People\u2019s Hospital of Deyang City, DeYang, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of Southwest Medical University, Cangzhou City, Sichuan Province, LuZhou, SiChuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"bibr1-0300060520904842","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrneurol.2014.121","volume":"10","author":"Berg BVD","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"bibr2-0300060520904842","first-page":"e18672","volume":"14","author":"Zhu Z","year":"2014","journal-title":"Hepat Mon"},{"key":"bibr3-0300060520904842","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13075-018-1546-7","volume":"20","author":"Zhang QB","year":"2018","journal-title":"Arthritis Res 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