{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:50:47Z","timestamp":1777726247004,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis was performed to evaluate the optimal discontinuation of dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation in acute coronary syndrome (ACS) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search was conducted without language restrictions using PubMed, the Cochrane Library, and Clinical Trials.gov from January 2008 to July 2019. Studies that met the following criteria were included: (1) randomized trials that compared DAPT durations of &lt;12 months (\u201cshort DAPT\u201d) or \u226512 months (\u201clong DAPT\u201d); (2) studies that included data on patients with ACS; and (3) studies that included data on outcomes. The outcomes were pooled using the Mantel\u2013Haenszel model, generating relative risk (RR) and 95% confidence intervals (CI). Statistical heterogeneity was evaluated using the Cochrane Q statistic P-value and I\n                      <jats:sup>2<\/jats:sup>\n                      value. Publication bias was assessed by visually inspecting the funnel plots.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight studies comprising 10,537 participants were included in the analysis. The primary endpoint was not different between short-term and long-term DAPT (RR, 1.11; 95% CI, 0.92\u20131.34).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A meta-analysis of the available evidence suggests that DAPT can be reduced to 3 or 6 months without increasing the risk of cardiovascular and cerebrovascular events in patients with ACS who are undergoing DES implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520915052","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T06:32:37Z","timestamp":1586413957000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Duration of dual antiplatelet therapy in patients with acute coronary syndrome undergoing drug-eluting stent implantation: A meta-analysis"],"prefix":"10.1177","volume":"48","author":[{"given":"Xue","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-7449","authenticated-orcid":false,"given":"Wei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"key":"bibr1-0300060520915052","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000350"},{"key":"bibr2-0300060520915052","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2017.05.018"},{"key":"bibr3-0300060520915052","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60314-6"},{"key":"bibr4-0300060520915052","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.07.044"},{"key":"bibr5-0300060520915052","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"bibr6-0300060520915052","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30493-8"},{"key":"bibr7-0300060520915052","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.05.029"},{"key":"bibr8-0300060520915052","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2017-0017"},{"key":"bibr9-0300060520915052","first-page":"1034","volume":"38","author":"Palmerini 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