{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:17:34Z","timestamp":1791944254373,"version":"4.3.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300428, 81800167"],"award-info":[{"award-number":["81300428, 81800167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Diffuse large B-cell lymphoma (DLBCL) is the most common adult non-Hodgkin lymphoma (NHL) and is highly invasive, with a poor prognosis. The main clinical treatment for DLBCL involves chemotherapy or a combination of chemotherapy and targeted drugs. CD56 expression is considered as an indicator of poor prognosis in patients with acute myeloid leukemia and anaplastic large cell lymphoma; however, its role in DLBCL remains unclear. We report on a patient with CD56-positive DLBCL\/leukemia with BCL6\/ MYC double-hit, and DDX3X, LRP1B, SIN3A, and GNA13 gene mutations (stage IVA, prognostic index aaIPI\u2009=\u20092 points). The patient was treated with cyclophosphamide and prednisone pre-chemotherapy plus R-Hyper-CVAD AB and DA-EPOCH regimens. Lumbar puncture combined with intrathecal injection was performed to prevent central nervous system infiltration during hospitalization, and complete remission was confirmed. We also reviewed the literature to clarify the relevance of the unique clinical features associated with this case.<\/jats:p>","DOI":"10.1177\/0300060520918087","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T05:08:02Z","timestamp":1588568882000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["CD56-positive diffuse large B-cell lymphoma\/leukemia with\n                    <i>BCL6\/MYC<\/i>\n                    double-hit and multiple gene mutations: an indicator of poor prognosis?"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-0456","authenticated-orcid":false,"given":"Yanquan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, National and Fujian Provincial Key Laboratory of Hematology, Fuzhou, Fujian province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhen","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, National and Fujian Provincial Key Laboratory of Hematology, Fuzhou, Fujian province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Awal Issah","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, National and Fujian Provincial Key Laboratory of Hematology, Fuzhou, Fujian province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, National and Fujian Provincial Key Laboratory of Hematology, Fuzhou, Fujian province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, National and Fujian Provincial Key Laboratory of Hematology, Fuzhou, Fujian province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fujian Medical University Union Hospital, Fujian Institute of Hematology, National and Fujian Provincial Key Laboratory of Hematology, Fuzhou, Fujian province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"bibr1-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(92)90350-C"},{"key":"bibr2-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.07.011"},{"key":"bibr3-0300060520918087","first-page":"1300","volume":"51","author":"Mechtersheimer G","year":"1991","journal-title":"Cancer Res"},{"key":"bibr4-0300060520918087","first-page":"437","volume":"127","author":"Fatma K","year":"2018","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"bibr5-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002100"},{"key":"bibr6-0300060520918087","first-page":"78","volume":"45","author":"Wang JC","year":"2016","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"bibr7-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1179\/102453309X12583347113573"},{"key":"bibr8-0300060520918087","first-page":"3023","volume":"6","author":"Gu MJ","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"bibr9-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-203250"},{"key":"bibr10-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010201)91:3<525::AID-CNCR1030>3.0.CO;2-U"},{"key":"bibr11-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-011-0104-9"},{"key":"bibr12-0300060520918087","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20110048"},{"key":"bibr13-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05493.x"},{"key":"bibr14-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04098.x"},{"key":"bibr15-0300060520918087","doi-asserted-by":"publisher","DOI":"10.4103\/sajc.sajc_65_18"},{"key":"bibr16-0300060520918087","first-page":"343","volume":"39","author":"Chen B","year":"2010","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"bibr17-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1111\/his.12884"},{"key":"bibr18-0300060520918087","first-page":"1229","volume":"19","author":"Teoh CS","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"key":"bibr19-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.1999.00929.x"},{"key":"bibr20-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00893.x"},{"key":"bibr21-0300060520918087","doi-asserted-by":"publisher","DOI":"10.5603\/FHC.2011.0025"},{"key":"bibr22-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1097\/01.pai.0000208279.66189.43"},{"key":"bibr23-0300060520918087","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-014-0072-1"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520918087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520918087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520918087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:46:03Z","timestamp":1777459563000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520918087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1177\/0300060520918087"],"URL":"https:\/\/doi.org\/10.1177\/0300060520918087","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]},"article-number":"0300060520918087"}}