{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:52:12Z","timestamp":1777726332855,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Blast crisis develops in a minority of patients with chronic myeloid leukemia even in the era of tyrosine kinase inhibitor (TKI) therapy. Reports suggest that we know little about the mechanism of BCR-ABL and AML1-ETO co-expression in blast crisis of chronic myeloid leukemia, and that other chromosomal abnormalities also coexist. Here, we document an unusual and interesting case of a 51-year-old female diagnosed in the chronic phase of chronic myeloid leukemia. After undergoing TKI treatment for 3 months, her bone marrow aspirates in the chronic phase had transformed to blast crisis. Molecular genetic testing indicated she was positive for p210 form of BCR-ABL (copy number decreased from 108.91% to 56.96%) and AML1-ETO fusion (copy number, 5.65%) genes and had additional chromosomal abnormalities of t(8; 21)(q22; q22)\/t(9; 22)(q34; q11), t(2; 5)(p24; q13) and an additional +8 chromosome.<\/jats:p>","DOI":"10.1177\/0300060520919237","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T04:25:07Z","timestamp":1588652707000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-0222","authenticated-orcid":false,"given":"Cheng-Cheng","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan li","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, People\u2019s Republic of 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