{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:51:15Z","timestamp":1777726275775,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg\u2013Strauss syndrome, is eosinophil-rich, necrotizing granulomatous inflammation often involving the respiratory tract. Furthermore, EGPA is necrotizing vasculitis that predominantly affects small to medium vessels and is associated with asthma and eosinophilia. Most patients with EGPA have sinusitis and some complain of hearing loss and refractory otitis media with effusion. Systemic use of immunosuppressants and glucocorticoids is currently recommended, despite the inevitable associated side effects. However, systemic treatment is not always effective for nasal and ear symptoms. We report a case of EGPA with refractory otitis media and chronic sinusitis, which were resistant to systemic high-dose steroids and immunosuppressants. However, these symptoms responded well to functional endoscopic sinus surgery and myringotomy and grommet insertion. We also administered budesonide nasal irrigation and glucocorticoid injection by intratympanic and postaural methods in this patient. The therapeutic effect was satisfactory.<\/jats:p>","DOI":"10.1177\/0300060520920049","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T23:00:42Z","timestamp":1588114842000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of surgery and topical medication on eosinophilic granulomatosis with polyangiitis with otitis media and sinusitis: a case report"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-0426","authenticated-orcid":false,"given":"Zijing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Peking University People\u2019s Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Peking University People\u2019s Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Peking University People\u2019s Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"bibr1-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"bibr2-0300060520920049","first-page":"277","volume":"27","author":"Churg J","year":"1951","journal-title":"Am J Pathol"},{"key":"bibr3-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1002\/art.20077"},{"key":"bibr4-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.04.022"},{"key":"bibr5-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2010.05.003"},{"key":"bibr6-0300060520920049","first-page":"485","volume":"22","author":"Papadimitraki ED","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"bibr7-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330806"},{"key":"bibr8-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.004"},{"key":"bibr9-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500437435"},{"key":"bibr10-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1159\/000442040"},{"key":"bibr11-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199601000-00003"},{"key":"bibr12-0300060520920049","first-page":"14110","volume":"8","author":"Li X","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"bibr13-0300060520920049","first-page":"443","volume":"50","author":"Editorial Board of Chinese Journal of Otorhinolaryngology H, Neck S, Society of Otorhinolaryngology H,","year":"2015","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"bibr14-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2018.09.002"},{"key":"bibr15-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000212"},{"key":"bibr16-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21280"},{"key":"bibr17-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21096"},{"key":"bibr18-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21047"},{"key":"bibr19-0300060520920049","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21189"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520920049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520920049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520920049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:45:55Z","timestamp":1777459555000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520920049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/0300060520920049"],"URL":"https:\/\/doi.org\/10.1177\/0300060520920049","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"article-number":"0300060520920049"}}