{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:52:42Z","timestamp":1777726362918,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["8177050365"],"award-info":[{"award-number":["8177050365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Postoperative neurocognitive disorder (PND) is a main complication that is commonly seen postoperatively in elderly patients. The underlying mechanism remains unclear, although neuroinflammation has been increasingly observed in PND. Atorvastatin is a pleiotropic agent with proven anti-inflammatory effects. In this study, we investigated the effects of atorvastatin on a PND mouse model after peripheral surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>The mice were randomized into five groups. The PND models were established, and an open field test and fear condition test were performed. Hippocampal inflammatory cytokine expression was determined using ELISA. Peroxisome proliferator-activated receptor-gamma (PPAR\u03b3) expression in the hippocampus was tested using qRT-PCR and western blot analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>On day 1 after surgery, inflammatory cytokines such as tumor necrosis factor-\u03b1, interleukin-1\u03b2, and interleukin-6 showed a significant increase in the hippocampus, with prominent cognitive impairment. Atorvastatin treatment improved cognitive function in the mouse model, attenuated neuroinflammation, and increased PPAR\u03b3 expression in the hippocampus. However, treatment with the PPAR\u03b3 antagonist GW9662 partially reversed the protective effects of atorvastatin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicated that atorvastatin improves several hippocampal functions and alleviates inflammation in PND mice after surgery, probably through a PPAR\u03b3-involved signaling pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520924251","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T12:01:02Z","timestamp":1589544062000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Atorvastatin protects against postoperative neurocognitive disorder via a peroxisome proliferator-activated receptor-gamma signaling pathway in mice"],"prefix":"10.1177","volume":"48","author":[{"given":"Yinan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changwei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danxu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"},{"name":"Department of Anesthesiology, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2353-2184","authenticated-orcid":false,"given":"Anshi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"bibr1-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2571080"},{"key":"bibr2-0300060520924251","first-page":"846","volume":"41","author":"Wang Y","year":"2016","journal-title":"Zhong Nan Da Xue Bao Yi Xue Ban"},{"key":"bibr3-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209284"},{"key":"bibr4-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.04.004"},{"key":"bibr5-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004082"},{"key":"bibr6-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-11488-6_3"},{"key":"bibr7-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.12.003"},{"key":"bibr8-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.10.002"},{"key":"bibr9-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1159\/000335783"},{"key":"bibr10-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.07.020"},{"key":"bibr11-0300060520924251","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18362"},{"key":"bibr12-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01272-X"},{"key":"bibr13-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(03)00101-3"},{"key":"bibr14-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1650110"},{"key":"bibr15-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707442200"},{"key":"bibr16-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.05.112"},{"key":"bibr17-0300060520924251","first-page":"3113","volume":"21","author":"Wang HK","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"bibr18-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.01.028"},{"key":"bibr19-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.04.026"},{"key":"bibr20-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-016-0834-4"},{"key":"bibr21-0300060520924251","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0598-3"},{"key":"bibr22-0300060520924251","doi-asserted-by":"crossref","unstructured":"Barone R, Rizzo R, Tabb\u00ec G, et\u00a0al.  Nuclear peroxisome proliferator-activated Receptors (PPARs) as therapeutic targets of resveratrol for autism spectrum disorder. Int J Mol Sci 2019;  20(8): 1878\u20131894.","DOI":"10.3390\/ijms20081878"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520924251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520924251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520924251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:46:10Z","timestamp":1777459570000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520924251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1177\/0300060520924251"],"URL":"https:\/\/doi.org\/10.1177\/0300060520924251","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]},"article-number":"0300060520924251"}}