{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:23Z","timestamp":1777726463209,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate adipocytokine expression levels, platelet-to-lymphocyte ratio (PLR) and transforming growth factor (TGF)-\u03b21\/Smad signaling activity in diabetic patients with pulmonary infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty-two type 2 diabetic patients with pulmonary infection were included in the observation group and 75 patients with simple type 2 diabetes were recruited into the control group. The fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and PLR in the two groups were compared. Complement-C1q\/tumor necrosis factor related protein 3 (CTRP-3), complement-C1q\/tumor necrosis factor related protein 9 (CTRP-9), leptin, adiponectin, and TGF-\u03b21\/Smad signaling pathway activity in peripheral blood mononuclear cells (PBMCs) was detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with patients in the control group, patients in the observation group presented with increased levels of FGB, HbA1c, and leptin, an increase in the PLR, and decreased serum CTRP-3, CTRP-9, and adiponectin levels. TGF-\u03b21, p-Smad2, and p-Smad3 protein expression levels were up-regulated in PBMCs from patients in the observation group compared with the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results show that in type 2 diabetic patients with pulmonary infection, adipocytokine expression is altered, PLR is disturbed, and the TGF-\u03b21\/Smad signaling pathways in PBMCs are significantly activated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520926006","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T07:55:17Z","timestamp":1592812517000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Adipocytokine expression, platelet-to-lymphocyte ratio and TGF-\n                    <b>\u03b2<\/b>\n                    1\/Smad signaling activity in diabetic patients complicated with pulmonary infection"],"prefix":"10.1177","volume":"48","author":[{"given":"Mei","family":"Zha","sequence":"first","affiliation":[{"name":"Department of Infection Management, The People\u2019s Hospital of Jianyang City, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-8951","authenticated-orcid":false,"given":"Xiao-Bing","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Infection Management, The People\u2019s Hospital of Jianyang City, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical Centre of Dujiangyan City, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Infection Management, The People\u2019s Hospital of Jianyang City, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The People\u2019s Hospital of Jianyang City, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infection Management, Sichuan Provincial Fourth People\u2019s Hospital, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, The People\u2019s Hospital of Jianyang City, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Chengdu Second People\u2019s Hospital, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Liver Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Wei","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Infection Management, The People\u2019s Hospital of Jianyang City, Chengdu, Sichuan Province, 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