{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:27Z","timestamp":1777726467009,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of multiple- versus single-dose gonadotropin-releasing hormone agonist (GnRH-a) addition to luteal phase support (LPS), in patients with a first in vitro fertilization (IVF) failure associated with luteal phase deficiency (LPD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty patients with a first IVF failure associated with LPD were randomly assigned into single-dose and multiple-dose GnRH-a groups. In the second IVF attempt, patients in the single-dose group were given standard LPS plus a single dose of GnRH-a 6 days after oocyte retrieval. Patients in the multiple-dose group received standard LPS plus 14 daily injections of GnRH-a. Children conceived were followed up for 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pregnancy (67.5% vs. 42.5%), clinical pregnancy (50.0% vs. 22.5%), and live birth rates (42.5% vs. 20.0%) were significantly higher in the multiple-dose versus single-dose GnRH-a group. Patients in the multiple-dose GnRH-a group had significantly higher progesterone levels 14 days after oocyte recovery (35.9 vs. 21.4 ng\/mL). No significant difference existed in the status at birth or developmental and behavior assessments of 2-year-old children conceived in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Daily addition of GnRH-a to standard LPS can achieve better pregnancy outcomes with a sustained safety profile in patients with a first IVF failure associated with LPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520926026","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T05:54:18Z","timestamp":1591250058000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Multiple-dose versus single-dose gonadotropin-releasing hormone agonist after first in vitro fertilization failure associated with luteal phase deficiency: A randomized controlled trial"],"prefix":"10.1177","volume":"48","author":[{"given":"Danni","family":"Qu","sequence":"first","affiliation":[{"name":"Medical Center for Human Reproduction, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-4558","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Center for Human Reproduction, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"bibr1-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31825cab55"},{"key":"bibr2-0300060520926026","first-page":"CD004830","volume":"3","author":"Daya S","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr3-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del072"},{"key":"bibr4-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12770"},{"key":"bibr5-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.08.019"},{"key":"bibr6-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh235"},{"key":"bibr7-0300060520926026","first-page":"CD009154","volume":"10","author":"Van Der Linden M","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr8-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-8-107"},{"key":"bibr9-0300060520926026","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00210"},{"key":"bibr10-0300060520926026","first-page":"216","volume":"2","author":"Tesarik J","year":"2019","journal-title":"Curr Opin Gynecol Obstet"},{"key":"bibr11-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56815-0"},{"key":"bibr12-0300060520926026","doi-asserted-by":"publisher","DOI":"10.3109\/09513599409072451"},{"key":"bibr13-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1298742"},{"key":"bibr14-0300060520926026","first-page":"96","volume":"16","author":"Zafardoust S","year":"2015","journal-title":"J Reprod Infertil"},{"key":"bibr15-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.03.215"},{"key":"bibr16-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.10.031"},{"key":"bibr17-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138210"},{"key":"bibr18-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61794-4"},{"key":"bibr19-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00536-7"},{"key":"bibr20-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00602.x"},{"key":"bibr21-0300060520926026","first-page":"CD009154","volume":"7","author":"Van Der Linden M","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr22-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh830"},{"key":"bibr23-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del173"},{"key":"bibr24-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/727569"},{"key":"bibr25-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.04.004"},{"key":"bibr26-0300060520926026","doi-asserted-by":"publisher","DOI":"10.1080\/09513590310001651830"},{"key":"bibr27-0300060520926026","unstructured":"Cahill D. 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