{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:55Z","timestamp":1777726495228,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The sedative effects of dexmedetomidine (Dex) are similar to natural sleep, with easy wakening following Dex administration, and Dex has minor effects on breathing, reducing emergence agitation in children. The aim of this study was to systematically evaluate the effects of Dex on recovery quality in children following general anaesthesia with sevoflurane, to aid clinical decision making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant randomized controlled trials published before August 2019 were searched and selected from databases. Two researchers independently screened the literature, extracted data, and assessed included studies for bias risk. Meta-analysis was performed using Stata 14.0 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 24 publications. Following general anaesthesia by sevoflurane, Dex was associated with reduced occurrence of emergence agitation (odds ratio [OR] 0.16, 95% confidence interval [CI] 0.11, 0.25) and nausea and vomiting (OR 0.40, 95% CI 0.24, 0.60), along with shortened eye-opening time (standardized mean difference [SMD] 0.72, 95% CI 0.41, 1.03), shortened extubation time (SMD 0.54, 95% CI 0.28, 0.81), and reduced duration of post-anaesthesia care unit (PACU) stay (SMD 0.29, 95% CI 0.08, 0.51) versus placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dexmedetomidine has positive effects on recovery quality in children undergoing general anaesthesia with sevoflurane.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520927530","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T05:02:19Z","timestamp":1593061339000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Dexmedetomidine in children undergoing general anaesthesia with sevoflurane: a meta-analysis and systematic review"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-8033","authenticated-orcid":false,"given":"Wen","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Children\u2019s Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Centre for Child Health and Disorders; China International Science and Technology Cooperation base of Child development and Critical Disorders; Chongqing Key Laboratory of Paediatrics, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DongWei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Children\u2019s Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Centre for Child Health and Disorders; China International Science and Technology Cooperation base of Child development and Critical Disorders; Chongqing Key Laboratory of Paediatrics, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuLin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Chongqing Emergency Medical Centre, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"bibr1-0300060520927530","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.199852"},{"key":"bibr2-0300060520927530","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13116"},{"key":"bibr3-0300060520927530","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000321"},{"key":"bibr4-0300060520927530","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.203020"},{"key":"bibr5-0300060520927530","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12867"},{"key":"bibr6-0300060520927530","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162785"},{"key":"bibr7-0300060520927530","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bjan.2018.05.002","volume":"68","author":"Abdel-Rahman K","year":"2018","journal-title":"Rev Bras Anestesiol"},{"key":"bibr8-0300060520927530","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S196075"},{"key":"bibr9-0300060520927530","doi-asserted-by":"publisher","DOI":"10.1177\/0300060517699467"},{"key":"bibr10-0300060520927530","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2016.02.015"},{"key":"bibr11-0300060520927530","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7191"},{"key":"bibr12-0300060520927530","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"bibr13-0300060520927530","unstructured":"Higgins JP, Green S (eds).\n                      Cochrane handbook for systematic reviews of interventions: Version 5.1.0 [updated March 2011]\n                      . 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