{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:55:24Z","timestamp":1777726524220,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2018JY0415"],"award-info":[{"award-number":["2018JY0415"]}]},{"name":"the Military Medical Innovation Capability Enhancement Program of the First Affiliated Hospital of Army Medical University","award":["SWH2019QNLC-05"],"award-info":[{"award-number":["SWH2019QNLC-05"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical features and outcomes of cryptococcal meningitis (CM) in HIV-negative patients with and without lung infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the medical records of HIV-negative patients with CM admitted to two university hospitals in Southwest China over the past 5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy-one patients were included, of whom 35 (49.3%) had lung disease. Compared with patients without lung infection, CM patients with lung infection tended to be male and younger (\u226430 years), experienced more fever, less vomiting and fewer central nervous system symptoms; more often had low white blood cell (WBC) counts (&lt;20\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \/L), and fewer often had ethmoid sinusitis, maxillary sinusitis, paranasal sinusitis, and otitis media. Cryptococcus neoformans isolates from these patients were sensitive to itraconazole, voriconazole, fluconazole, and amphotericin B but resistant to flucytosine. CM patients with lung infection had higher mortality at discharge compared with patients without lung infection (8.6% vs. 0%). Multivariable analyses showed that a WBC count &lt;20\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \/L was significantly associated with poor treatment outcome (odds ratio 0.01, 95% confidence interval 0\u20130.83).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      HIV-negative CM patients with lung infections tended to be male and younger. Fever, fewer central nervous system symptoms, and WBC counts &lt;20\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \/L were characteristic of this patient group.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520929591","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T04:20:43Z","timestamp":1591935643000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of cryptococcal meningitis in HIV-negative patients with and without lung infections"],"prefix":"10.1177","volume":"48","author":[{"given":"Ming","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Department of Pharmacy, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3825-5378","authenticated-orcid":false,"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Affiliated Hospital of North Sichuan Medical College, Nanchong, 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