{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:18:05Z","timestamp":1783030685921,"version":"3.54.6"},"reference-count":20,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Empirical determination of phenylalanine (Phe) tolerance in patients with phenylketonuria (PKU) relies on frequent assessment of blood Phe concentrations in relation to Phe intake from detailed meal records. This study aimed to determine Phe tolerance in twin pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The reviewed cases included three women with PKU who each had a singleton and twin pregnancy (i.e., they were pregnant twice). All patients were under regular supervision to maintain Phe concentrations in a steady state and determine safe Phe intake. Restriction of Phe in the patient\u2019s diet was determined depending on the amount of Phe intake, which allowed for stable blood Phe concentrations within the target range.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all three patients with PKU, the ratio of Phe tolerance during the course of the twin and singleton pregnancies was &lt;1 for most of the pregnancy. The ratio of the increase in Phe tolerance between 29 and 34 weeks of gestation and that between 15 and 28 weeks of gestation was 0.66 and 1.17, 0.51 and 0.14, and 0.76 and 1.42 in the twin and singleton pairs of pregnancies, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study shows that Phe tolerance in a twin pregnancy is not greater than that in a singleton pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520934623","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T01:20:56Z","timestamp":1600824056000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of phenylalanine tolerance in singleton and twin pregnancies in patients with phenylketonuria"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8606-2509","authenticated-orcid":false,"given":"Kamil Konrad","family":"Hozyasz","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, State School of Higher Education, Bia\u0142a Podlaska, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"\u017b\u00f3\u0142kowska","sequence":"additional","affiliation":[{"name":"PKU Polyclinic, Institute of Mother and Child, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Chy\u017c","sequence":"additional","affiliation":[{"name":"PKU Polyclinic, Institute of Mother and Child, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"bibr1-0300060520934623","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0685-2"},{"key":"bibr2-0300060520934623","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.157"},{"key":"bibr3-0300060520934623","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.placenta.2018.01.010","volume":"63","author":"Weiner E","year":"2018","journal-title":"Placenta"},{"key":"bibr4-0300060520934623","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0022-3476(82)80504-0","volume":"100","author":"Levy HL","year":"1982","journal-title":"J Pediatr"},{"key":"bibr5-0300060520934623","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/BF01799521","volume":"13","author":"Naughten E","year":"1990","journal-title":"J Inherit Metab 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