{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:59:35Z","timestamp":1782889175169,"version":"3.54.5"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fund of Key Laboratory of Hormones and Development","award":["2017DX03"],"award-info":[{"award-number":["2017DX03"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800767, 81502659"],"award-info":[{"award-number":["81800767, 81502659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Natural Science Fund","award":["18JCYBJC25500"],"award-info":[{"award-number":["18JCYBJC25500"]}]},{"name":"Research Project of Tianjin Municipal Commission of Health and Family Planning on Traditional Chinese Medicine and Combination of Chinese Traditional and Western Medicine","award":["2017168"],"award-info":[{"award-number":["2017168"]}]},{"name":"Scientific Research Funding of Tianjin Medical University Chu Hsien-I Memorial Hospital","award":["2018ZDKF04"],"award-info":[{"award-number":["2018ZDKF04"]}]},{"name":"The Science & Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2016YD12"],"award-info":[{"award-number":["2016YD12"]}]},{"name":"The Science & Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2017KJ211"],"award-info":[{"award-number":["2017KJ211"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Previous studies suggest that small intestinal bacterial overgrowth (SIBO) is associated with type 2 diabetes. However, few studies have evaluated the association between SIBO and beta-cell function in type 2 diabetes. The aim of this study was to evaluate whether beta-cell function was associated with SIBO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      One hundred four patients with type 2 diabetes were included in this study. Based on the presence of SIBO, the patients were divided into SIBO-positive and SIBO-negative groups. Oral glucose tolerance tests were performed. Insulin sensitivity was measured using 1\/homeostasis model assessment of insulin resistance (1\/HOMA-IR) and the insulin sensitivity index (ISIM). Insulin release was calculated by HOMA-\u03b2, early-phase insulin secretion index InsAUC\n                      <jats:sub>30<\/jats:sub>\n                      \/GluAUC\n                      <jats:sub>30<\/jats:sub>\n                      , and total-phase insulin secretion index InsAUC\n                      <jats:sub>120<\/jats:sub>\n                      \/GluAUC\n                      <jats:sub>120<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the SIBO-negative group, patients in the SIBO-positive group showed a higher glucose level at 120 minutes, HbA1c, 1\/HOMA-IR, and ISIM and a lower HOMA-\u03b2 level, early-phase InsAUC\n                      <jats:sub>30<\/jats:sub>\n                      \/GluAUC\n                      <jats:sub>30<\/jats:sub>\n                      , and total-phase InsAUC\n                      <jats:sub>120<\/jats:sub>\n                      \/GluAUC\n                      <jats:sub>120<\/jats:sub>\n                      . Multiple linear regression analysis showed that body mass index, glucose at 0 minutes, and SIBO were independently associated with the early-phase and total-phase insulin secretion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SIBO may be involved in lower levels of insulin release and worse glycemic control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520937866","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T07:36:22Z","timestamp":1595316982000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between small intestinal bacterial overgrowth and beta-cell function of type 2 diabetes"],"prefix":"10.1177","volume":"48","author":[{"given":"Li-hui","family":"Yan","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9827-6261","authenticated-orcid":false,"given":"Biao","family":"Mu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, China"},{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Pan","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, China"},{"name":"Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-nan","family":"Shi","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, 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Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin, 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