{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:52:08Z","timestamp":1777726328756,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Uniwersytet Medyczny w Lublinie","doi-asserted-by":"publisher","award":["329"],"award-info":[{"award-number":["329"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Tubal diseases are responsible for 25% to 35% of female infertility. Laparoscopic chromopertubation is the gold standard for assessing tubal patency when female infertility is suspected. Intravasation is a complication of intrauterine procedures involving the passage of fluid filling the uterine cavity into the bloodstream through endometrial vessels (from the myometrial veins to the uterine venous plexuses). This complication has been described during hysterosalpingography and sonohysterosalpingography. We herein present a report of three cases in which severe intravasation occurred during laparoscopic chromopertubation using methylene blue as a contrast agent. The intravasation manifested as green urine (i.e., the \u201cgreen urine sign\u201d). The presence of methylene blue in the urine and blood was confirmed by laboratory tests. All three patients had risk factors for intravasation as described in the literature (unilateral or bilateral tubal obstruction, endometriosis, and previous intrauterine procedures for Mullerian duct anomalies and Asherman\u2019s syndrome). The green urine sign appeared a few hours after laparoscopic chromopertubation and spontaneously resolved after 24 hours. Cystoscopy was performed to rule out bladder injury. All three patients required only clinical observation.<\/jats:p>","DOI":"10.1177\/0300060520942083","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T05:21:42Z","timestamp":1598851302000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Green urine sign after laparoscopic chromopertubation as an effect of severe contrast intravasation: a report of three cases"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3582-067X","authenticated-orcid":false,"given":"Piotr","family":"Szkodziak","sequence":"first","affiliation":[{"name":"Third Chair and Department of Gynecology, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Third Chair and Department of Gynecology, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Szkodziak","sequence":"additional","affiliation":[{"name":"Third Chair and Department of Gynecology, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Buszewicz","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic Toxicology, Chair and Department of Forensic Medicine, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Czuczwar","sequence":"additional","affiliation":[{"name":"Third Chair and Department of Gynecology, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Wo\u017aniak","sequence":"additional","affiliation":[{"name":"Third Chair and Department of Gynecology, Medical University of Lublin, Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"bibr1-0300060520942083","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200406000-00004"},{"key":"bibr2-0300060520942083","author":"Ott J","year":"2019","journal-title":"J Minim Invasive Gynecol"},{"key":"bibr3-0300060520942083","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.5.725"},{"key":"bibr4-0300060520942083","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60309-3"},{"key":"bibr5-0300060520942083","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcv030"},{"key":"bibr6-0300060520942083","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.896103"},{"key":"bibr7-0300060520942083","doi-asserted-by":"publisher","DOI":"10.4103\/2156-7514.124105"},{"key":"bibr8-0300060520942083","first-page":"18","volume":"6","author":"Chang M","year":"2012","journal-title":"J Radiol Case 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