{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:19:02Z","timestamp":1787937542254,"version":"build-2784847793"},"reference-count":28,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["23179"],"award-info":[{"award-number":["23179"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to determine whether estradiol (E2) levels (Day 3 and fold change to Day 10), antral follicle count (AFC), and number of ova collected could predict ovarian hyperstimulation syndrome (OHSS) and culdocentesis intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of patient charts between January 2008 and December 2017. OHSS was defined using American Society for Reproductive Medicine criteria. Predictability was evaluated by measuring the area under the receiver operating characteristic curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 319 women (166 controls, 153 OHSS, of whom 54 had severe OHSS). The OHSS group had higher E2\n                      <jats:sub>Day\u20093<\/jats:sub>\n                      (249\u2009\u00b1\u2009177 vs. 150\u2009\u00b1\u2009230 ng\/L), E2\n                      <jats:sub>FoldChange<\/jats:sub>\n                      (32.2\u2009\u00b1\u200929.1 vs. 20.1\u2009\u00b1\u200923.8), AFC (18.2\u2009\u00b1\u20099.1 vs. 11.6\u2009\u00b1\u20098.3), and number of ova collected (21.1\u2009\u00b1\u20099.0 vs. 10.1\u2009\u00b1\u20096.5). E2\n                      <jats:sub>Day\u20093<\/jats:sub>\n                      (AUC\u2009=\u20090.76, 95%CI: 0.71\u20130.82), E2\n                      <jats:sub>FoldChange<\/jats:sub>\n                      (AUC\u2009=\u20090.71, 95%CI: 0.65\u20130.77), AFC (AUC\u2009=\u20090.75, 95%CI: 0.70\u20130.81), and number of ova collected (AUC\u2009=\u20090.85, 95%CI: 0.81\u20130.89) were predictive for OHSS. All variables were predictive for culdocentesis intervention (E2\n                      <jats:sub>Day\u20093<\/jats:sub>\n                      : AUC\u2009=\u20090.63, 95%CI: 0.55\u20130.70; E2\n                      <jats:sub>FoldChange<\/jats:sub>\n                      : AUC\u2009=\u20090.63, 95%CI: 0.55\u20130.71; AFC: AUC\u2009=\u20090.74, 95%CI: 0.68\u20130.80; number of ova collected: AUC\u2009=\u20090.80, 95%CI: 0.75\u20130.85).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Day 3 E2 levels and number of ova collected predict patients who could develop OHSS and may require culdocentesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520945551","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T13:20:11Z","timestamp":1597324811000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Prediction of severe ovarian hyperstimulation syndrome in women undergoing\n                    <i>in vitro<\/i>\n                    fertilization using estradiol levels, collected ova, and number of follicles"],"prefix":"10.1177","volume":"48","author":[{"given":"Ivan","family":"Madrazo","sequence":"first","affiliation":[{"name":"Instituto de Infertilidad y Gen\u00e9tica, Ingenes, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monserrat Fabiola","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Instituto de Infertilidad y Gen\u00e9tica, Ingenes, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josue Jonathan","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Instituto de Infertilidad y Gen\u00e9tica, Ingenes, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginna","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Instituto de Infertilidad y Gen\u00e9tica, Ingenes, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Instituto de Infertilidad y Gen\u00e9tica, Ingenes, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo M.","family":"Porchia","sequence":"additional","affiliation":[{"name":"Departamento de Toxicolog\u00eda, Centro de Investigaci\u00f3n de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Elba","family":"Gonzalez-Mejia","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, Puebla, Puebla, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2849-7587","authenticated-orcid":false,"given":"Esther","family":"L\u00f3pez-Bayghen","sequence":"additional","affiliation":[{"name":"Departamento de Toxicolog\u00eda, Centro de Investigaci\u00f3n de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, M\u00e9xico City, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"bibr1-0300060520945551","first-page":"248","volume":"43","author":"Namavar Jahromi BM","year":"2018","journal-title":"Iran J Med Sci"},{"key":"bibr2-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.12.2756"},{"key":"bibr3-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0889-x"},{"key":"bibr4-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8651"},{"key":"bibr5-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.010801"},{"key":"bibr6-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/3.3.255"},{"key":"bibr7-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.11.004"},{"key":"bibr8-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2019.05.018"},{"key":"bibr9-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60633-5"},{"key":"bibr10-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13569"},{"key":"bibr11-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00491-X"},{"key":"bibr12-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-32"},{"key":"bibr13-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2017.1331048"},{"key":"bibr14-0300060520945551","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1102879"},{"key":"bibr15-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt062"},{"key":"bibr16-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.02.001"},{"key":"bibr17-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.03.028"},{"key":"bibr18-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.110"},{"key":"bibr19-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000182795.31757.CE"},{"key":"bibr20-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12515"},{"key":"bibr21-0300060520945551","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903287482"},{"key":"bibr22-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.048"},{"key":"bibr23-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14684"},{"key":"bibr24-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1501"},{"key":"bibr25-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4994-z"},{"key":"bibr26-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-0151-6"},{"key":"bibr27-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9387-6"},{"key":"bibr28-0300060520945551","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.6.559"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520945551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520945551","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520945551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:46:09Z","timestamp":1777459569000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520945551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1177\/0300060520945551"],"URL":"https:\/\/doi.org\/10.1177\/0300060520945551","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]},"article-number":"0300060520945551"}}