{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:53:09Z","timestamp":1777726389695,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Youth Development Fundation of the First Hospital of Jilin University","award":["JDYY102019004"],"award-info":[{"award-number":["JDYY102019004"]}]},{"name":"he Science and Technology Development Program of Jilin Province","award":["20190103079JH"],"award-info":[{"award-number":["20190103079JH"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract with both epithelial and neuroendocrine components. We describe a case of a 57-year-old man who presented with yellow sclera and dark urine. Contrast-enhanced computed tomography (CT) showed enlargement of the intra and extrahepatic bile ducts and a neoplastic lesion at the end of the common bile duct which was indistinguishable from the adjacent head of the pancreas and duodenum. A pancreaticoduodenectomy was performed and histopathological examination of resected samples showed that tumour was a complex lesion with adenocarcinoma and neuroendocrine components positive for neuroendocrine markers (chromogranin A and synaptophysin) with a Ki-67 labelling index of 40%. The patient was diagnosed with MANEC in the ampulla of Vater with a neuroendocrine carcinoma component of approximately 70%. Ampullary MANECs are highly aggressive tumours with a high risk for distant metastases and a poor prognosis. Therefore, establishing a standard therapeutic strategy is crucial.<\/jats:p>","DOI":"10.1177\/0300060520947918","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T12:10:59Z","timestamp":1598271059000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report"],"prefix":"10.1177","volume":"48","author":[{"given":"Xu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hepatology, The first hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5104-0219","authenticated-orcid":false,"given":"Dezhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The first hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The first hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyue","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The first hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"bibr1-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-014-9313-z"},{"key":"bibr2-0300060520947918","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0102-RS"},{"key":"bibr3-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519850391"},{"key":"bibr4-0300060520947918","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11662"},{"key":"bibr5-0300060520947918","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2011.11.2.122"},{"key":"bibr6-0300060520947918","doi-asserted-by":"publisher","DOI":"10.9738\/INTSURG-D-13-00161.1"},{"key":"bibr7-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0169-6"},{"key":"bibr8-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0557"},{"key":"bibr9-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-019-01009-2"},{"key":"bibr10-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0985-4"},{"key":"bibr11-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1159\/000501200"},{"key":"bibr12-0300060520947918","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i4.1329"},{"key":"bibr13-0300060520947918","doi-asserted-by":"publisher","DOI":"10.3390\/cancers4010011"},{"key":"bibr14-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1159\/000369071"},{"key":"bibr15-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006225"},{"key":"bibr16-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.084954"},{"key":"bibr17-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016000"},{"key":"bibr18-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1212-4"},{"key":"bibr19-0300060520947918","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-8001-3"},{"key":"bibr20-0300060520947918","first-page":"5517","volume":"34","author":"Vanacker L","year":"2014","journal-title":"Anticancer Res"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520947918","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520947918","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520947918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:46:14Z","timestamp":1777459574000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520947918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1177\/0300060520947918"],"URL":"https:\/\/doi.org\/10.1177\/0300060520947918","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]},"article-number":"0300060520947918"}}