{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:53:19Z","timestamp":1777726399288,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the epidemiology of intravenous midazolam-induced postoperative expressive aphasia (EA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The incidence rate, risk ratio, and contributing factors to intravenous midazolam-induced postoperative EA were analyzed retrospectively in 6756 orthopedic patients. A telephone interview was conducted with patients with EA after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients were allocated to either the midazolam group (n\u2009=\u20096178) or no-midazolam group (n\u2009=\u2009578). Twelve patients developed EA in the midazolam group, with an incidence of 0.19%, and no patient developed EA in the no-midazolam group. The mean age of EA patients was 70 years, and 92% were women. Among them, 75% received general anesthesia, and the mean dose of midazolam was 1.8\u2009mg. EA was reversed in nine of 12 (75%) patients within 4 minutes of flumazenil administration, and &gt;60 minutes were required to reverse EA in the other three patients (25%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intravenous midazolam administration for preoperative sedation caused transient EA in 0.19% of patients, especially elderly women who received general anesthesia, and EA could be reversed by flumazenil.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520948751","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T07:49:55Z","timestamp":1598514595000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Postoperative expressive aphasia associated with intravenous midazolam administration: a 5-year retrospective case-control study"],"prefix":"10.1177","volume":"48","author":[{"given":"Saecheol","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Daejeon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihyun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Daejeon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-2096","authenticated-orcid":false,"given":"Sujin","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Daejeon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0152-2869","authenticated-orcid":false,"given":"Yoo Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Saint Vincent\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"bibr1-0300060520948751","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000994"},{"key":"bibr2-0300060520948751","doi-asserted-by":"publisher","DOI":"10.1213\/XAA.0000000000000140"},{"key":"bibr3-0300060520948751","unstructured":"Food and drug administration. (2017) Versed and Aphonia - from FDA reports. [www document] http:\/\/www.ehealthme.com\/ds\/versed\/aphonia\/ (accessed on 4 2017)"},{"key":"bibr4-0300060520948751","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100403"},{"key":"bibr5-0300060520948751","unstructured":"Aninda BA, Wroten M. NCBI Bookshelf. StatPearls. Broca Aphasia, https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK436010 (2019, accessed 5 January 2020)."},{"key":"bibr6-0300060520948751","unstructured":"Brookshire R.\n                      Introduction to neurogenic communication disorders\n                      . 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