{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:53:20Z","timestamp":1777726400283,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patients\u2019 median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520949039","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T05:42:50Z","timestamp":1598852570000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Retrospective analysis of clinical characteristics of 405 patients with COVID-19"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-7890","authenticated-orcid":false,"given":"Ting","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China"},{"name":"Jianghan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueting","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junsheng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"bibr1-0300060520949039","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.009"},{"key":"bibr2-0300060520949039","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"bibr3-0300060520949039","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"bibr4-0300060520949039","doi-asserted-by":"publisher","DOI":"10.1111\/all.14238"},{"key":"bibr5-0300060520949039","doi-asserted-by":"publisher","DOI":"10.1590\/1980-549720200021"},{"key":"bibr6-0300060520949039","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m764"},{"key":"bibr7-0300060520949039","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12851"},{"key":"bibr8-0300060520949039","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"bibr9-0300060520949039","first-page":"100","volume":"28","author":"Guan 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