{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:53:32Z","timestamp":1777726412114,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Minhang District Natural Science Foundation of Shanghai","award":["2017MHZ06"],"award-info":[{"award-number":["2017MHZ06"]}]},{"name":"Medical Key Faculty Foundation of Shanghai","award":["ZK2019B15"],"award-info":[{"award-number":["ZK2019B15"]}]},{"name":"Science Foundation of Shanghai Fifth People's Hospital","award":["2018WYZT03"],"award-info":[{"award-number":["2018WYZT03"]}]},{"name":"Health Profession Clinical Foundation of Shanghai Municipal Health Commission","award":["201840119"],"award-info":[{"award-number":["201840119"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of our study was to explore the association between serum cystatin C (CysC) and euthyroid Hashimoto\u2019s thyroiditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>There were 119 female euthyroid Hashimoto\u2019s thyroiditis patients and 225 healthy controls who were recruited. Serum CysC, thyroid function, thyroid autoantibodies, fasting glucose, liver enzymes, and lipid profile were determined. Clinical parameters were compared between two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum CysC levels were significantly higher in euthyroid Hashimoto\u2019s thyroiditis patients compared with controls. In the lowest, middle, and highest tertile groups of CysC, the percentage of Hashimoto\u2019s thyroiditis was 15.9%, 34.2%, and 53.5%, respectively. The percentage of Hashimoto\u2019s thyroiditis was significantly higher in the highest tertile than in the lowest and middle tertiles. Spearman\u2019s correlation analysis showed that serum CysC levels were negatively correlated with free triiodothyronine (FT\n                      <jats:sub>3<\/jats:sub>\n                      ), and positively correlated with serum thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb). Logistic regression analysis showed that serum CysC was independently related to the status of euthyroid Hashimoto\u2019s thyroiditis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study shows the first evidence suggesting that serum CysC levels are positively correlated with TPOAb and TGAb. Serum CysC might underlie the pathophysiologic features of euthyroid Hashimoto\u2019s thyroiditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520952973","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T20:47:18Z","timestamp":1598906838000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum cystatin C is closely associated with euthyroid Hashimoto\u2019s thyroiditis in adult female Chinese patients"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4791-469X","authenticated-orcid":false,"given":"Qiaojing","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shanghai Fifth People\u2019s Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai Fifth People\u2019s Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wencai","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Shanghai Fifth People\u2019s Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai Fifth People\u2019s Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-8690","authenticated-orcid":false,"given":"Heyuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shanghai Fifth People\u2019s Hospital, Fudan University, Shanghai, 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