{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:44:51Z","timestamp":1777725891105,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hysterectomy is associated with severe postoperative pain. The relative efficacy of pregabalin compared with other treatments for post-hysterectomy pain is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the PubMed, Cochrane Library, and Web of Science databases for studies that compared the use of pregabalin and placebo for reducing pain in patients undergoing hysterectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This meta-analysis showed that pregabalin had limited pain-relieving effects at 2, 6, 24, and 48 hours after hysterectomy compared with placebo. Pregabalin significantly reduced postoperative nausea and vomiting. However, there was no significant difference in postoperative sedation or visual disturbances between patients treated with pregabalin and placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pregabalin is not clinically superior to placebo in terms of reducing pain intensity and morphine consumption in patients undergoing hysterectomy. However, the limitations of this meta-analysis mean that more high-quality randomized controlled trials are necessary to verify our pooled results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520954720","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T03:24:16Z","timestamp":1608261856000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Pregabalin does not decrease acute pain or postoperative nausea and vomiting after hysterectomy: a meta-analysis"],"prefix":"10.1177","volume":"48","author":[{"given":"Jie","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Gynecology, Jingjiang People\u2019s Hospital, Taizhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-8850","authenticated-orcid":false,"given":"Juan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Jingjiang People\u2019s Hospital, Taizhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqin","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Jingjiang People\u2019s Hospital, Taizhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-fang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Jingjiang People\u2019s Hospital, Taizhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2018-100024"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.03.013"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006286"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.19082\/2602"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.455003.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007714"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011581"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001749"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000809"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-023600"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2020.33.1.3"},{"key":"e_1_3_2_13_2","first-page":"Cd007076","article-title":"Pregabalin for neuropathic pain in adults.","volume":"1","author":"Derry S","year":"2019","unstructured":"Derry S, Bell RF, Straube S, et\u00a0al. Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev 2019; 1: Cd007076. DOI: 10.1002\/14651858.CD007076.pub3.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.01.015"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.04.002"},{"key":"e_1_3_2_16_2","unstructured":"Higgins JPT Green S. Cochrane Handbook for Systematic Reviews of Interventions version 5.1.0 [http:\/\/www.cochrane-handbook.org]. (2011)."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529786"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_3_2_20_2","first-page":"1318","article-title":"Effects of pregabalin on post operative morphine consumption and pain after abdominal hysterectomy with\/without salpingo-oophorectomy: a randomized, double-blind trial","volume":"92","author":"Ittichaikulthol W","year":"2009","unstructured":"Ittichaikulthol W, Virankabutra T, Kunopart M, et\u00a0al. Effects of pregabalin on post operative morphine consumption and pain after abdominal hysterectomy with\/without salpingo-oophorectomy: a randomized, double-blind trial. J Med Assoc Thai 2009; 92: 1318\u20131323.","journal-title":"J Med Assoc Thai"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_2_22_2","first-page":"471","article-title":"Bias in meta-analysis detected by a simple, graphical test. Increase in studies of publication bias coincided with increasing use of meta-analysis","volume":"316","author":"Song F","year":"1998","unstructured":"Song F, Gilbody S. Bias in meta-analysis detected by a simple, graphical test. Increase in studies of publication bias coincided with increasing use of meta-analysis. BMJ 1998; 316: 471.","journal-title":"BMJ"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2307\/2533446"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32835800e0"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-014-0147-4"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.84097"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01821.x"},{"key":"e_1_3_2_28_2","first-page":"14","article-title":"Effect of pre-emptive pregabalin on pain intensity and morphine requirement after hysterectomy","volume":"43","author":"Przesmycki K","year":"2011","unstructured":"Przesmycki K, Wiater-Koziol E, Kotarski J, et\u00a0al. [ Effect of pre-emptive pregabalin on pain intensity and morphine requirement after hysterectomy]. Anestezjol Intens Ter 2011; 43: 14\u201317.","journal-title":"Anestezjol Intens Ter"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.34591"},{"key":"e_1_3_2_30_2","first-page":"9","article-title":"Pregabalin for the treatment of postoperative pain: results from three controlled trials using different surgical models.","volume":"8","author":"Singla NK","year":"2015","unstructured":"Singla NK, Chelly JE, Lionberger DR, et\u00a0al. Pregabalin for the treatment of postoperative pain: results from three controlled trials using different surgical models. J Pain Res 2015; 8: 9\u201320. DOI: 10.2147\/jpr.s67841.","journal-title":"J Pain Res"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.curtheres.2011.06.004"},{"key":"e_1_3_2_32_2","first-page":"481","article-title":"The effects of preoperative pregabalin on postoperative analgesia and morphine consumption after abdominal hysterectomy","volume":"2014","author":"Eman A","year":"2014","unstructured":"Eman A, Bilir A, Beyaz SG. The effects of preoperative pregabalin on postoperative analgesia and morphine consumption after abdominal hysterectomy. Acta Med Mediterr 2014; 2014: 481.","journal-title":"Acta Med Mediterr"},{"key":"e_1_3_2_33_2","article-title":"Role of preoperative pregabalin in reducing inhalational anaesthetic requirements in abdominal hysterectomy: randomized controlled trial","author":"El-Refai NA","year":"2019","unstructured":"El-Refai NA, Shehata JH, Lotfy A, et\u00a0al. Role of preoperative pregabalin in reducing inhalational anaesthetic requirements in abdominal hysterectomy: randomized controlled trial. Minerva Anestesiol 2019. DOI: 10.23736\/s0375-9393.19.13734-0.","journal-title":"Minerva Anestesiol"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-017-2406-3"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.15.01202"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520954720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520954720","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520954720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:43:56Z","timestamp":1777459436000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520954720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/0300060520954720"],"URL":"https:\/\/doi.org\/10.1177\/0300060520954720","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"article-number":"0300060520954720"}}