{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:56Z","timestamp":1777726496503,"version":"3.51.4"},"reference-count":77,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>At the end of 2019, novel coronavirus (COVID-19) infection was detected in Wuhan City, Hubei Province, China. The COVID-19 infection characteristics include a long incubation period, strong infectivity, and high fatality rate, and it negatively affects human health and social development. COVID-19 has become a common problem in the global medical and health system. It is essentially an acute self-limiting disease. Patients with severe COVID-19 infection usually progress to acute respiratory distress syndrome, sepsis, metabolic acidosis that is difficult to correct, coagulation dysfunction, multiple organ failure, and even death within a short period after onset. There remains a lack of effective drugs for such patients clinically. Mesenchymal stem cells (MSCs) are expected to reduce the risk of complications and death in patients because they have strong anti-inflammatory and immunomodulatory capabilities, which can improve the microenvironment, promote neovascularization, and enhance tissue repair capabilities. China is currently conducting several clinical trials on MSCs for the treatment of COVID-19. Here, we review the research progress related to using stem cells to treat patients with COVID-19.<\/jats:p>","DOI":"10.1177\/0300060520955063","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:56:05Z","timestamp":1600995365000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Mesenchymal stem cell research progress for the treatment of COVID-19"],"prefix":"10.1177","volume":"48","author":[{"given":"Dezhi","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Respiratory, Songshan Lake Central Hospital, Dongguan, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanrong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Songshan Lake Central Hospital, Dongguan, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhirong","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Songshan Lake Central Hospital, Dongguan, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Songshan Lake Central Hospital, Dongguan, Guangdong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1370-7967","authenticated-orcid":false,"given":"Shixiong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"bibr1-0300060520955063","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22211.2"},{"key":"bibr2-0300060520955063","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"bibr3-0300060520955063","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0228"},{"key":"bibr4-0300060520955063","unstructured":"World Health Organization (WHO). 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