{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:14:18Z","timestamp":1783404858681,"version":"3.54.6"},"reference-count":31,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Qingyuan People\u2019s Hospital Innovation Fund","award":["No. 20180031"],"award-info":[{"award-number":["No. 20180031"]}]},{"name":"Guangdong Medical Science and Technology Research Fund Project","award":["No.2020553"],"award-info":[{"award-number":["No.2020553"]}]},{"name":"Qingyuan Science and Technology Project","award":["No. 2018 B036"],"award-info":[{"award-number":["No. 2018 B036"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The pericentric inversion of chromosome 9 (inv9) is one of the most common structural balanced chromosomal variations, and it is considered to be a normal population variant. The aim of this study was to re-evaluate the clinical impact of patients with inv9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied the karyotypes from 4853 patients at a single center and retrospectively reviewed their clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 67 inv9 patients among 2988 adults, and 62 of them showed different clinical features, including male and female infertility, oligoasthenozoospermia, and azoospermia. Thirty-one cases of inv9 were found in 1865 fetuses, including two cases in chorionic villus (6.90%) and 29 in amniotic fluid (1.67%), but there were no cases in umbilical cord blood. The rates of fetal phenotype abnormal and adverse pregnancy outcome with inv9 in the chorionic villus were 100.00% (2\/2), while only 17.24% (5\/29) in the amniotic fluid showed abnormalities, among which 60.00% (3\/5) had adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although there is no clear evidence that inv9 is pathogenic, the genetic counseling on inv9 in early pregnancy and adults needs to be given more attention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520957820","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T04:06:26Z","timestamp":1600747586000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Analysis of the clinical features of pericentric inversion of chromosome 9"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5279-6045","authenticated-orcid":false,"given":"Xiaolei","family":"Xie","sequence":"first","affiliation":[{"name":"Prenatal Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University-Qingyuan People\u2019s Hospital, Qingyuan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuguang","family":"Li","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University-Qingyuan People\u2019s Hospital, Qingyuan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihe","family":"Tan","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University-Qingyuan People\u2019s Hospital, Qingyuan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Tang","sequence":"additional","affiliation":[{"name":"Prenatal Diagnosis Center, The Sixth Affiliated Hospital of Guangzhou Medical University-Qingyuan People\u2019s Hospital, Qingyuan, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"bibr1-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260116"},{"key":"bibr2-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8166-6-14"},{"key":"bibr3-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1159\/000453574"},{"key":"bibr4-0300060520957820","first-page":"300060519875893","author":"Xie X","year":"2019","journal-title":"J Int Med Res"},{"key":"bibr5-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.05.071"},{"key":"bibr6-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1373-4"},{"key":"bibr7-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2006.00725.x"},{"key":"bibr8-0300060520957820","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2010.51.5.775"},{"key":"bibr9-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1007\/BF01883320"},{"key":"bibr10-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp048"},{"key":"bibr11-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioz084"},{"key":"bibr12-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0836-8"},{"key":"bibr13-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-029354"},{"key":"bibr14-0300060520957820","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92159-F"},{"key":"bibr15-0300060520957820","doi-asserted-by":"crossref","unstructured":"McGowan-Jordan J, Simons A, Schmid M. 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