{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:29:18Z","timestamp":1790285358962,"version":"4.1.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>When a patient harbors two or more neuroendocrine tumors (NETs), it can be difficult to determine whether they are double primary tumors or metastases. A 60-year-old man complained of voice change lasting 1 month. On physical examination and imaging, a 1.8-cm mass was observed in his epiglottis, and a laser epiglottectomy was performed. Upon microscopic examination, the tumor consisted of medium-sized ovoid or short spindle cells. Immunohistochemical staining of the tumor cells was positive for synaptophysin, chromogranin, and calcitonin but negative for CD56; the Ki-67 proliferation index was approximately 5%. The patient was diagnosed with atypical carcinoid tumor. In 2015, a hypermetabolic endobronchial tumor was identified in the left lower lobe by positron emission tomography-computed tomography. Bronchoscopic biopsy revealed palisading large tumor cells with high nuclear-cytoplasmic ratio, frequent mitoses, and necrosis. The tumor cells were positive for CD56 and negative for cytokeratin-7, thyroid transcription factor-1, P40, synaptophysin, chromogranin, and calcitonin; the Ki-67 proliferation index was approximately 90%. Overall histologic findings were consistent with large cell neuroendocrine carcinoma rather than metastatic atypical carcinoid tumor. Detailed clinical and pathological review are essential to differentiate between metastatic NET and double primary NETs and, therefore, to provide the best management of the patient.<\/jats:p>","DOI":"10.1177\/0300060520962928","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T02:57:07Z","timestamp":1604977027000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Metachronous double primary neuroendocrine tumors in larynx and lung: a case report"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-3548","authenticated-orcid":false,"given":"In Hye","family":"Song","sequence":"first","affiliation":[{"name":"Department of Hospital Pathology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hospital Pathology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Il","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Kil","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyo-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Hospital Pathology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"bibr1-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1159\/000085237"},{"key":"bibr2-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90951-6"},{"key":"bibr3-0300060520962928","volume-title":". WHO classification of head and neck tumours","author":"El-Naggar AK","year":"2017","edition":"4"},{"key":"bibr4-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2017.04.005"},{"key":"bibr5-0300060520962928","volume-title":". WHO classification of tumours of the digestive system","author":"Bosman FT","year":"2010","edition":"4"},{"key":"bibr6-0300060520962928","volume-title":". WHO classification of tumours of the lung, pleura, thymus and heart","author":"Travis WD","year":"2015","edition":"4"},{"key":"bibr7-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1177\/1758835919853673"},{"key":"bibr8-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.04.002"},{"key":"bibr9-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000876"},{"key":"bibr10-0300060520962928","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2012.707254"},{"key":"bibr11-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-018-9545-4"},{"key":"bibr12-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001204"},{"key":"bibr13-0300060520962928","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2016.03.028"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520962928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520962928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520962928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:16Z","timestamp":1777459876000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520962928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/0300060520962928"],"URL":"https:\/\/doi.org\/10.1177\/0300060520962928","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"article-number":"0300060520962928"}}