{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:22:24Z","timestamp":1777728144224,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>We herein describe the preoperative and postoperative clinical data of a patient with a rare case of vulvar malignant melanoma and discuss her clinical characteristics and prognosis. After surgical resection and immunotherapy, the patient\u2019s illness continued to worsen. She then received local vulvar radiotherapy. However, further treatment was discontinued because of intolerable complications of radiotherapy, and the patient died about 18 months postoperatively. Management of vulvar malignant melanoma is challenging. No unified, effective, and standardized diagnostic and treatment plan has been established for this disease. Surgery remains the primary treatment modality for locally resectable vulvar malignant melanoma. Radiation therapy and chemotherapy do not benefit survival. Encouragingly, however, immunotherapy and targeted therapy have shown clinical efficacy in metastatic vulvar malignant melanoma.<\/jats:p>","DOI":"10.1177\/0300060520965398","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T01:46:30Z","timestamp":1605663990000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple metastases after surgery for a rare vulvar malignant melanoma combined with immunotherapy: a case report"],"prefix":"10.1177","volume":"48","author":[{"given":"Wenjing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingzhi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0235-3286","authenticated-orcid":false,"given":"Yiming","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhumei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"bibr1-0300060520965398","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30473"},{"key":"bibr2-0300060520965398","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00487-x"},{"key":"bibr3-0300060520965398","first-page":"1257","volume":"17","author":"Wohlmuth C","year":"2019","journal-title":"J Dtsch Dermatol Ges"},{"key":"bibr4-0300060520965398","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000198"},{"key":"bibr5-0300060520965398","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940515)73:10<2626::AID-CNCR2820731026>3.0.CO;2-U"},{"key":"bibr6-0300060520965398","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-260"},{"key":"bibr7-0300060520965398","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000768"},{"key":"bibr8-0300060520965398","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709684"},{"key":"bibr9-0300060520965398","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2012.713938"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520965398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520965398","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520965398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:22Z","timestamp":1777459882000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520965398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/0300060520965398"],"URL":"https:\/\/doi.org\/10.1177\/0300060520965398","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"article-number":"0300060520965398"}}