{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:55:18Z","timestamp":1787871318589,"version":"build-2784847793"},"reference-count":57,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Nanjing Medical Science and Technology Development Fund","award":["QRX17060"],"award-info":[{"award-number":["QRX17060"]}]},{"name":"Shire Biopharmaceutical Fund, Jiangsu Pharmaceutical Association","award":["S201606"],"award-info":[{"award-number":["S201606"]}]},{"name":"Nanjing University Hospital Management Research Institute 2017 Project","award":["NDYG2017012"],"award-info":[{"award-number":["NDYG2017012"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis explored the safety and effectiveness of different anticoagulant regimens after left atrial appendage occlusion (LAAO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Databases, such as PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Library, were searched to identify eligible studies according to the inclusion criteria. The incidences of events, including device-related thrombus (DRT) formation, stroke, systemic thromboembolism, bleeding, cardiovascular mortality, and all-cause mortality, were analyzed using R version 3.2.3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The screening retrieved 32 studies, including 36 study groups and 4,474 patients. The incidence of outcomes after LAAO was calculated via meta-analysis. In the subgroup analysis, the rates of DRT formation, cardiovascular mortality, and all-cause mortality were significantly different among different antithrombotic methods. Single antiplatelet therapy was associated with the highest rate of adverse events, followed by dual antiplatelet therapy (DAPT). Vitamin K antagonists (VKAs) and new oral anticoagulants (NOACs) carried lower rates of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anticoagulant therapy had better safety and efficacy than antiplatelet therapy. Thus, for patients with nonabsolute anticoagulant contraindications, anticoagulant therapy rather than DAPT should be actively selected. NOACs displayed potential for further development, and these treatments might represent alternatives to VKAs in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520966478","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T20:34:40Z","timestamp":1606682080000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Meta-analysis of postoperative antithrombotic therapy after left atrial appendage occlusion"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-1549","authenticated-orcid":false,"given":"Shu-yue","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Jiangsu Nanjing, China"},{"name":"School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xinjiang Yili Friendship Hospital, Xinjiang Yili China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Jiangsu Nanjing, China"},{"name":"School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Jiangsu Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Jiangsu Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-6566","authenticated-orcid":false,"given":"Hang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School, Jiangsu Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,29]]},"reference":[{"key":"bibr1-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"bibr2-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2018.08.008"},{"key":"bibr3-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13254"},{"key":"bibr4-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.09.025"},{"key":"bibr5-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.11.030"},{"key":"bibr6-0300060520966478","first-page":"222","volume":"32","author":"Sahiner L","year":"2020","journal-title":"J Invasive Cardiol"},{"key":"bibr7-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.05.048"},{"key":"bibr8-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.02.041"},{"key":"bibr9-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.03.039"},{"key":"bibr10-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301799"},{"key":"bibr11-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.11.001"},{"key":"bibr12-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"bibr13-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13838"},{"key":"bibr14-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13796"},{"key":"bibr15-0300060520966478","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.recesp.2018.03.020","volume":"72","author":"Lopez-Minguez JR","year":"2019","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"bibr16-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1111\/jce.13385"},{"key":"bibr17-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2018.1455946"},{"key":"bibr18-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-0222"},{"key":"bibr19-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.05.016"},{"key":"bibr20-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005997"},{"key":"bibr21-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.02.120"},{"key":"bibr22-0300060520966478","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2017.0245"},{"key":"bibr23-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.05.023"},{"key":"bibr24-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2017.02.013"},{"key":"bibr25-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.10.020"},{"key":"bibr26-0300060520966478","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.199832"},{"key":"bibr27-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2016.09.006"},{"key":"bibr28-0300060520966478","first-page":"440","volume":"109","author":"Guerios EE","year":"2017","journal-title":"Arq Bras Cardiol"},{"key":"bibr29-0300060520966478","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2017.0017"},{"key":"bibr30-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2017.04.018"},{"key":"bibr31-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.016"},{"key":"bibr32-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.08.075"},{"key":"bibr33-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-309150"},{"key":"bibr34-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0910-8"},{"key":"bibr35-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22478"},{"key":"bibr36-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.04.031"},{"key":"bibr37-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-306332"},{"key":"bibr38-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-015-0053-z"},{"key":"bibr39-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0828"},{"key":"bibr40-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25329"},{"key":"bibr41-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.24872"},{"key":"bibr42-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2012.10.011"},{"key":"bibr43-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.035"},{"key":"bibr44-0300060520966478","first-page":"S173","volume":"78","author":"Lam YY","year":"2011","journal-title":"Catheter Cardiovasc Interv"},{"key":"bibr45-0300060520966478","author":"Hernandez JM","year":"2017","journal-title":"Cirugia Cardiovascular"},{"key":"bibr46-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"bibr47-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.01.039"},{"key":"bibr48-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15192"},{"key":"bibr49-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2018.1510316"},{"key":"bibr50-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2015.988612"},{"key":"bibr51-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.04.004"},{"key":"bibr52-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux313"},{"key":"bibr53-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.03.253"},{"key":"bibr54-0300060520966478","doi-asserted-by":"publisher","DOI":"10.15420\/icr.2018.21.3"},{"key":"bibr55-0300060520966478","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26903"},{"key":"bibr56-0300060520966478","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00042"},{"key":"bibr57-0300060520966478","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.12.116"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520966478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520966478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520966478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:51:24Z","timestamp":1777459884000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520966478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/0300060520966478"],"URL":"https:\/\/doi.org\/10.1177\/0300060520966478","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"article-number":"0300060520966478"}}