{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:22:43Z","timestamp":1777728163290,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671928"],"award-info":[{"award-number":["81671928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate the effect of gonadotropin dose and endometrial thickness (EMT) on pregnancy outcome in patients undergoing intrauterine insemination (IUI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed data from 361 patients with unexplained infertility or polycystic ovarian syndrome (PCOS) who underwent 930\u2009IUI cycles treated with gonadotropins. Then, we measured the effects of gonadotropins and EMT on the clinical pregnancy rate. Finally, we assessed the association of various doses of gonadotropins on EMT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The dose of gonadotropins given and thickness of the endometrium were higher in the pregnancy group than in the nonpregnancy group (636.0 vs. 600.0\u2009IU for gonadotropin dose; 9.15 vs. 8.70\u2009mm for EMT). Clinical pregnancy rates were significantly improved by increasing the dose of gonadotropins (9.1%, &lt;450\u2009IU; 16.2%, 450\u2013599\u2009IU; 18.6%, 600\u2013749\u2009IU, and 17.3%, \u2265750\u2009IU), or by increased EMT (0%, &lt;5.0\u2009mm; 12.2%, 5.0\u20136.9\u2009mm; 15.5%, 7.0\u201314.0\u2009mm; and 33.3%, &gt;14.0\u2009mm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increasing the dose of gonadotropins to stimulate one follicle to develop may benefit endometrial proliferation and improve\u2009IUI outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520966538","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T23:16:16Z","timestamp":1604013376000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of gonadotropins and endometrial thickness on pregnancy outcome in patients with unexplained infertility or polycystic ovarian syndrome undergoing intrauterine insemination"],"prefix":"10.1177","volume":"48","author":[{"given":"Qing","family":"Li","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Nanning Maternal and Child Health Care Hospital, Nanning, China"},{"name":"College of Biotechnology, Guilin Medical University, Guilin, Guangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maoling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Nanning Maternal and Child Health Care Hospital, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuxiu","family":"Deng","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Nanning Maternal and Child Health Care Hospital, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Tianlin People\u2019s Hospital, Baise, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Nanning Maternal and Child Health Care Hospital, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Ruan","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Nanning Maternal and Child Health Care Hospital, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofei","family":"Hu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Nanning Maternal and Child Health Care Hospital, Nanning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-5939","authenticated-orcid":false,"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biotechnology, Guilin Medical University, Guilin, Guangxi, 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