{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:23:20Z","timestamp":1777728200334,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>There is controversy whether nicorandil treatment has cardioprotective effects in patients with acute myocardial infarction (AMI) following percutaneous coronary intervention (PCI). This meta-analysis was conducted to assess the efficacy of nicorandil on functional and clinical outcomes after PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic databases were searched to retrieve studies that compared the effect of nicorandil with a control group in patients with AMI who underwent PCI. Outcomes related to coronary blood flow, and functional and clinical outcomes were extracted and a meta-analysis was performed. Trial sequential analysis was conducted to estimate the required sample size for statistical power.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-four trials involving 2965 patients with AMI were enrolled. Pooled results showed that nicorandil treatment significantly suppressed the incidence of no-reflow phenomenon and reperfusion arrhythmia after reperfusion, improved the left ventricular ejection fraction and left ventricular end-systolic volume index, and reduced major adverse cardiovascular events and cardiovascular death. Trial sequential analysis confirmed the effect of nicorandil in reducing the incidence of no-reflow phenomenon and follow-up major adverse cardiovascular events in patients with AMI after PCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that nicorandil treatment adjunctive to reperfusion therapy improves myocardial reperfusion, cardiac function, and clinical outcomes in patients with AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520967856","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T20:59:35Z","timestamp":1606683575000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of nicorandil treatment adjunctive to percutaneous coronary intervention in patients with acute myocardial infarction: a systematic review and meta-analysis"],"prefix":"10.1177","volume":"48","author":[{"given":"Jin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijuan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-6469","authenticated-orcid":false,"given":"Shan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,29]]},"reference":[{"key":"bibr1-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90700-B"},{"key":"bibr2-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.102867"},{"key":"bibr3-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.2.162"},{"key":"bibr4-0300060520967856","first-page":"139","volume":"69","author":"Liang T","year":"2017","journal-title":"Rev Invest Clin"},{"key":"bibr5-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.09.037"},{"key":"bibr6-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.042"},{"key":"bibr7-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-016-6668-z"},{"key":"bibr8-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078231"},{"key":"bibr9-0300060520967856","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2623"},{"key":"bibr10-0300060520967856","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-1588"},{"key":"bibr11-0300060520967856","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.906815"},{"key":"bibr12-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.01.011"},{"key":"bibr13-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61634-1"},{"key":"bibr14-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-007-0975-z"},{"key":"bibr15-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.62.183"},{"key":"bibr16-0300060520967856","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"bibr17-0300060520967856","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"bibr18-0300060520967856","unstructured":"Higgins JPT, Green S.\n                      Cochrane handbook for systematic reviews of interventions version 5.1.0\n                      . 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