{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:37:27Z","timestamp":1783082247459,"version":"3.54.6"},"reference-count":35,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["19ZR1447100"],"award-info":[{"award-number":["19ZR1447100"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of Shanghai Dermatology Hospital","award":["2018KYQD02"],"award-info":[{"award-number":["2018KYQD02"]}]},{"name":"Foundation of Shanghai Dermatology Hospital","award":["17HBDS08"],"award-info":[{"award-number":["17HBDS08"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study compared the diagnostic performance of alpha-fetoprotein (AFP) and des-gamma-carboxyprothrombin (DCP) in early-stage hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) under different backgrounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were enrolled and divided in four groups: chronic HBV infection (CHB), liver cirrhosis (LC), early-stage CHB-HCC, and early-stage LC-HCC. Serum AFP and DCP levels were measured. Receiver-operating characteristic (ROC) curve and area under the curve (AUC) analyses were applied to compare the diagnostic performance of DCP and AFP for HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 200 patients were enrolled, including 48, 64, 33, and 55 patients with CHB, LC, CHB-HCC, and LC-HCC, respectively. ROC curve analysis revealed that the AUCs of AFP, DCP, and their combination in differentiating early-stage LC-HCC from LC were 0.776, 0.758, and 0.786, respectively. The values of these markers in discriminating early-stage CHB-HCC from CHB were 0.828, 0.731, and 0.862, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DCP was inferior to AFP in differentiating early-stage CHB-HCC from CHB. However, AFP and DCP displayed similar performance in distinguishing early-stage LC-HCC and LC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520969087","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T10:46:45Z","timestamp":1604141205000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of serum AFP and DCP levels in the diagnosis of early-stage HBV-related HCC under different backgrounds"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2810-471X","authenticated-orcid":false,"given":"Ting","family":"Song","sequence":"first","affiliation":[{"name":"Department of Hepatology, The Sixth People\u2019s Hospital of Qingdao, Qingdao, Shandong, China"},{"name":"Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Sixth People\u2019s Hospital of Qingdao, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruopei","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Sixth People\u2019s Hospital of Qingdao, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The Sixth People\u2019s Hospital of Qingdao, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-4100","authenticated-orcid":false,"given":"Yun","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Dermatology Hospital, Tongji University, Shanghai, China"},{"name":"Tongji University Cancer Center, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"bibr1-0300060520969087","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27406"},{"key":"bibr2-0300060520969087","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"bibr3-0300060520969087","doi-asserted-by":"publisher","DOI":"10.4065\/82.8.967"},{"key":"bibr4-0300060520969087","doi-asserted-by":"crossref","unstructured":"Nagaratnam N, Nagaratnam K, Cheuk G. 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