{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:14:02Z","timestamp":1790828042225,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Co-reactivation of cytomegalovirus (CMV) and Epstein\u2013Barr virus (EBV) occurs in iatrogenically immunosuppressed patients, but the clinical relevance of this is unknown. We aimed to determine the frequency of EBV reactivation in patients with CMV viremia and to explore its clinical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum or plasma CMV and EBV DNA was detected by quantitative real-time PCR in 82 patients who received immunosuppressive therapy and\/or chemotherapy and underwent CMV antigenemia tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CMV DNA was positive in 55 patients, with EBV reactivation being found in 29 of these (52.7%). EBV co-reactivation was significantly associated with aging (&gt;64 years vs. \u226464 years, odds ratio 4.07, 95% confidence interval 1.06\u201315.6). When older patients were divided into two groups according to age, EBV co-reactivation occurred more frequently in early-old patients (aged 65\u201374 years) than in late-old patients (aged \u226575 years) (100.0% vs. 53.3%, respectively). Steroid pulse treatment was administered significantly more often in the early-old group than in those aged \u226464 years and \u226575 years (72.7% vs 27.6% vs 14.3%, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Co-reactivation of EBV in patients with CMV viremia highlighted early-old patients and may reflect treatment intensity as well as immunosenescence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520972880","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T20:46:11Z","timestamp":1606682771000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Frequent co-reactivation of Epstein\u2013Barr virus in patients with cytomegalovirus viremia under immunosuppressive therapy and\/or chemotherapy"],"prefix":"10.1177","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-1913","authenticated-orcid":false,"given":"Yuki","family":"Hatayama","sequence":"first","affiliation":[{"name":"Division of Clinical Laboratory, Tottori University Hospital, Yonago, Tottori, Japan"},{"name":"Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Laboratory, Tottori University Hospital, Yonago, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Motokura","sequence":"additional","affiliation":[{"name":"Division of Clinical Laboratory Medicine, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,29]]},"reference":[{"key":"bibr1-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1186\/2042-4280-2-6"},{"key":"bibr2-0300060520972880","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24050997"},{"key":"bibr3-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-205822"},{"key":"bibr4-0300060520972880","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.75.775"},{"key":"bibr5-0300060520972880","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9020125"},{"key":"bibr6-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098819"},{"key":"bibr7-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-9-22"},{"key":"bibr8-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000969"},{"key":"bibr9-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2000.140507.x"},{"key":"bibr10-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2007.01.005"},{"key":"bibr11-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23397"},{"key":"bibr12-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-9-1"},{"key":"bibr13-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-6-10"},{"key":"bibr14-0300060520972880","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180841"},{"key":"bibr15-0300060520972880","first-page":"217","volume":"59","author":"Hatayama Y","year":"2016","journal-title":"Yonago Acta Med"},{"key":"bibr16-0300060520972880","first-page":"1188","volume":"59","author":"Lo YM","year":"1999","journal-title":"Cancer Res"},{"key":"bibr17-0300060520972880","unstructured":"Fryer JF, Heath AB, Anderson R, et\u00a0al.  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