{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:44:39Z","timestamp":1777725879241,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Sj\u00f6gren\u2019s syndrome is an autoimmune disease that can affect multiple systems. Sj\u00f6gren\u2019s syndrome with motor neuron disease is rarely reported. Herein, we describe a patient with rapidly progressive motor neuron disease secondary to Sj\u00f6gren\u2019s syndrome. A 42-year-old woman was admitted to our hospital with a 2-month history of progressive limb weakness. Neurological assessment revealed fasciculation in the lower limbs and amyotrophy in the bilateral supraspinatus, interosseous, and thenar muscles. Serological examination and labial gland biopsy revealed Sj\u00f6gren\u2019s syndrome. In addition, electromyography demonstrated neurogenic damage to the upper and lower limbs. The patient received a short course of high-dose corticosteroids, intravenous immunoglobulins, and immunosuppressant treatment, including a weekly dose of 0.4 g cyclophosphamide and a daily dose of 0.2 g hydroxychloroquine. However, the patient\u2019s limb weakness was further aggravated and her respiratory function was compromised. Electromyography re-examination demonstrated extensive neurogenic damage, and she was diagnosed with Sj\u00f6gren\u2019s syndrome with motor neuron disease. The patient died of respiratory failure after 2 months. We suggest that more effective maintenance treatments should be sought. Further investigation is required to elucidate the association between autoimmune motor neuron disease and Sj\u00f6gren\u2019s syndrome.<\/jats:p>","DOI":"10.1177\/0300060520974465","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T02:29:02Z","timestamp":1606271342000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Sj\u00f6gren\u2019s syndrome with rapidly progressive motor neuron disease: a case report"],"prefix":"10.1177","volume":"48","author":[{"given":"Huijia","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, the First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhong","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shanghai Tong-Ren Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8148-3790","authenticated-orcid":false,"given":"Dihui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"bibr1-0300060520974465","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2012.06.002"},{"key":"bibr2-0300060520974465","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000141099.53742.16"},{"key":"bibr3-0300060520974465","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198207000-00004"},{"key":"bibr4-0300060520974465","first-page":"876","volume":"60","author":"Barendregt PJ","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"bibr5-0300060520974465","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.222109"},{"key":"bibr6-0300060520974465","first-page":"590292","volume":"2014","author":"Colaci M","year":"2014","journal-title":"Case Rep Neurol Med"},{"key":"bibr7-0300060520974465","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2018.75521"},{"key":"bibr8-0300060520974465","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00865"},{"key":"bibr9-0300060520974465","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01600"},{"key":"bibr10-0300060520974465","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199903)22:3<404::AID-MUS15>3.0.CO;2-E"},{"key":"bibr11-0300060520974465","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0846"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520974465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520974465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520974465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:43:54Z","timestamp":1777459434000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520974465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/0300060520974465"],"URL":"https:\/\/doi.org\/10.1177\/0300060520974465","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"article-number":"0300060520974465"}}