{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:55:26Z","timestamp":1777726526013,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Patients with anti-interferon (IFN)-\u03b3 autoantibodies have weakened immune defenses against intracellular pathogens. Because of its low incidence and non-specific symptoms, diagnosis of anti-IFN-\u03b3 autoantibody syndrome is difficult to establish during the early stages of infection. Here, we report a patient with high titers of serum anti-IFN-\u03b3 autoantibodies suffering from opportunistic infections. The patient presented with intermittent fever for 2 weeks. During his first hospitalization, he was diagnosed with Talaromyces marneffei pulmonary infection and successfully treated with antifungal therapy. However, multiple cervical lymph nodes subsequently became progressively enlarged. Mycobacterium abscessus infection was confirmed by positive cervical lymph node tissue cultures. High-titer serum anti-IFN-\u03b3 antibodies were also detected. Following anti- M. abscessus therapy, both his symptoms and lymph node lymphadenitis gradually improved. Anti-IFN-\u03b3 autoantibody syndrome should be considered in adult patients with severe opportunistic coinfections in the absence of other known risk factors.<\/jats:p>","DOI":"10.1177\/0300060520976471","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T21:51:18Z","timestamp":1610661078000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Coinfection by\n                    <i>Talaromyces marneffei<\/i>\n                    and\n                    <i>Mycobacterium abscessus<\/i>\n                    in a human immunodeficiency virus-negative patient with anti-interferon-\u03b3 autoantibody: a case report"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9335-2336","authenticated-orcid":false,"given":"Weizhong","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Jinhua Guangfu Hospital, Zhejiang, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Departments of Respiratory Medicine, Affiliated Hangzhou First People's Hospital, Nanjin Medical University, Hangzhou, Zhejiang, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China"},{"name":"Departments of Respiratory Medicine, Affiliated Hangzhou First People's Hospital, Nanjin Medical University, Hangzhou, Zhejiang, P.R. 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