{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:00:55Z","timestamp":1777726855879,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many studies have investigated the relationship between the interleukin-1\u03b2 gene ( IL1B) \u2212511C\/T polymorphism and the risk of Beh\u00e7et\u2019s disease (BD); however, the conclusions remain controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we systemically retrieved relevant studies from the Chinese Biomedicine Database, China National Knowledge Infrastructure, Embase, Cochrane Library, and PubMed databases. We then calculated the odds ratios (ORs) and 95% confidence intervals (CIs) using the meta-package Stata version 12.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The IL1B \u2212511C\/T polymorphism was not related to BD susceptibility using any of the tested models (C vs T: OR\u2009=\u20091.20, 95% CI\u2009=\u20090.97\u20131.49; CC vs TT: OR\u2009=\u20091.27, 95% CI\u2009=\u20090.95\u20131.70; CT vs TT: OR\u2009=\u20091.03, 95% CI\u2009=\u20090.781.36; dominant model: OR\u2009=\u20091.12, 95% CI\u2009=\u20090.87\u20131.46; recessive model: OR\u2009=\u20091.27, 95% CI\u2009=\u20090.89\u20131.82). Similarly, subgroup analysis including studies consistent with the Hardy\u2013Weinberg equilibrium revealed no association between the IL1B polymorphism and BD susceptibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta-analysis indicates that the IL1B \u2212511C\/T polymorphism is unlikely to affect the risk of BD; however, further large-scale, carefully designed studies are needed to verify these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520979860","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:01:27Z","timestamp":1614124887000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between\n                    <i>IL1B<\/i>\n                    \u2212511C\/T polymorphism and Beh\u00e7et\u2019s disease: a meta-analysis"],"prefix":"10.1177","volume":"49","author":[{"given":"Baogang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiac surgery, First Hospital, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Second Hospital, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuying","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, First hospital, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, First hospital, Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-6960","authenticated-orcid":false,"given":"Xiaxia","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Oncological gynecology, First hospital, Jilin University, Changchun, China Baogang Wang and Yihang Gao contributed equally to this work."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"bibr1-0300060520979860","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016886"},{"key":"bibr2-0300060520979860","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-002-0167-5"},{"key":"bibr3-0300060520979860","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0811014"},{"key":"bibr4-0300060520979860","doi-asserted-by":"publisher","DOI":"10.2174\/1568010053622894"},{"key":"bibr5-0300060520979860","first-page":"1544","volume":"20","author":"Mege 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