{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:57:50Z","timestamp":1784696270849,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In patients with acute liver injury caused by hepatic veno-occlusive disease (HVOD), molecular adsorbent recirculation system (MARS) may be used to improve liver function in conjunction with transjugular intrahepatic portosystemic shunt (TIPS) to reduce portal hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve patients were admitted to our hospital following treatment for HVOD for 10 to 21 days at other hospitals. All patients were treated with a combination of MARS and TIPS, and they were evaluated clinically including liver function tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After the initial treatment with MARS, liver function improved significantly in all patients. TIPS placement decreased the hepatic venous pressure gradient (HVPG) to 10.17\u2009\u00b1\u20092.26\u2009mmHg from a pre-TIPS HVPG of 23.58\u2009\u00b1\u20099.43\u2009mmHg. The outcomes of combination treatment with MARS and TIPS in 12 patients with HVOD were as follows: 1) improvement of various clinical and biological parameters leading to full recovery in 1 year in 6 patients; 2) full recovery following liver transplantation for acute liver failure in three patients; and 3) three patients died due to hepatic failure after TIPS placement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of MARS and TIPS creation is promising as a potential treatment for acute HVOD, and it showed an improvement in overall survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520980877","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T11:24:42Z","timestamp":1609241082000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of combination treatment with MARS and TIPS for hepatic veno-occlusive disease: a report of 12 cases"],"prefix":"10.1177","volume":"48","author":[{"given":"Li","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shandong Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Rongjun Hospital of Shandong Province, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7099-5769","authenticated-orcid":false,"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shandong Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"key":"bibr1-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23204"},{"key":"bibr2-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200311000-00010"},{"key":"bibr3-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.130"},{"key":"bibr4-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00918.x"},{"key":"bibr5-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-014-0242-x"},{"key":"bibr6-0300060520980877","doi-asserted-by":"publisher","DOI":"10.4065\/78.5.589"},{"key":"bibr7-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12558"},{"key":"bibr8-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701172"},{"key":"bibr9-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200005)64:1<32::AID-AJH6>3.0.CO;2-N"},{"key":"bibr10-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.52"},{"key":"bibr11-0300060520980877","first-page":"95","volume":"8","author":"Stegelmeier BL","year":"1999","journal-title":"J Nat Toxins"},{"key":"bibr12-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22772"},{"key":"bibr13-0300060520980877","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i29.3918"},{"key":"bibr14-0300060520980877","first-page":"197","volume":"10","author":"Shulman HM","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"bibr15-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290615"},{"key":"bibr16-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.9.1729"},{"key":"bibr17-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.03.117"},{"key":"bibr18-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702386"},{"key":"bibr19-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000225799.76828.ce"},{"key":"bibr20-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240321"},{"key":"bibr21-0300060520980877","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20773"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520980877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520980877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520980877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:44:18Z","timestamp":1777459458000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520980877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/0300060520980877"],"URL":"https:\/\/doi.org\/10.1177\/0300060520980877","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"article-number":"0300060520980877"}}