{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:55:54Z","timestamp":1777726554579,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of tumor necrosis factor (TNF)-\u03b1 small interfering (si)RNA alveolar epithelial cell (AEC)-targeting nanoparticles in lung injury is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty C57BL\/6J mice with sepsis were divided into normal, control, sham, 25 mg\/kg, 50 mg\/kg, and 100 mg\/kg siRNA AEC-targeting nanoparticles groups (n\u2009=\u200910 per group). The wet:dry lung weight ratio, and hematoxylin and eosin staining, western blotting, and enzyme-linked immunosorbent assays for inflammatory factors were conducted to compare differences among groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The wet:dry ratio was significantly lower in control and sham groups than other groups. TNF-\u03b1 siRNA AEC-targeting nanoparticles significantly reduced the number of eosinophils, with significantly lower numbers in the 50 mg\/kg group than in 25 mg\/kg and 100 mg\/kg groups. The nanoparticles also significantly reduced the expression of TNF-\u03b1, B-cell lymphoma-2, caspase 3, interleukin (IL)-1\u03b2, and IL-6, with TNF-\u03b1 expression being significantly lower in the 50 mg\/kg group than in 25 mg\/kg and 100 mg\/kg groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TNF-\u03b1 siRNA AEC-targeting nanoparticles appear to be effective at improving lung injury-related sepsis, and 50 mg\/kg may be a preferred dose option for administration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520984652","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T21:53:02Z","timestamp":1610661182000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Tumor necrosis factor-\u03b1 small interfering RNA alveolar epithelial cell-targeting nanoparticles reduce lung injury in C57BL\/6J mice with sepsis"],"prefix":"10.1177","volume":"49","author":[{"given":"Like","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengli","family":"Chen","sequence":"additional","affiliation":[{"name":"Burn Institute of PLA, Department of Burn Surgery, The First Affiliated Hospital. 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