{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:56:04Z","timestamp":1777726564300,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated the efficacy and safety of sugammadex doses calculated using corrected body weight (CBW) for reversing deep rocuronium-induced neuromuscular blockade (NMB) in morbidly obese patients undergoing laparoscopic bariatric surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and twenty-five morbidly obese patients were randomly assigned to three groups: (1) a CBW group, n\u2009=\u200950; (2) a total body weight (TBW) group, n\u2009=\u200950; and (3) a control group, n\u2009=\u200925. Deep NMB was maintained using a continuous infusion of rocuronium. At the reappearance of 1 to 2 post-tetanic counts (PTCs), 4\u2009mg\/kg sugammadex, calculated using CBW or TBW, were administered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All the participants in the CBW and TBW groups recovered to a train-of-four (TOF) ratio of 0.9 within 5 minutes. The recovery times from the start of sugammadex administration to a TOF ratio of 0.9 were 2.2\u2009\u00b1\u20090.7 and 2.0\u2009\u00b1\u20090.7 minutes in the CBW and TBW groups, respectively. Thus, a sugammadex dose calculated using CBW was not inferior to that calculated using TBW for the reversal of rocuronium-induced deep NMB in morbidly obese patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A dose of 4\u2009mg\/kg of sugammadex calculated using CBW is efficient and safe for the reversal of deep NMB after a continuous infusion of rocuronium in morbidly obese patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration Number<\/jats:title>\n                    <jats:p>ChiCTR1900028652 (Chinese Clinical Trial Registry, www.chictr.org.cn )<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0300060520985679","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T23:43:52Z","timestamp":1611704632000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of sugammadex doses calculated on the basis of corrected body weight and total body weight for the reversal of deep neuromuscular blockade in morbidly obese patients"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-6203","authenticated-orcid":false,"given":"Deming","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Fourth Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Fourth Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Fourth Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunming","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Fourth Affiliated Hospital of China Medical University, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"bibr1-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"bibr2-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"bibr3-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67483-1"},{"key":"bibr4-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5584"},{"key":"bibr5-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000367"},{"key":"bibr6-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-6307-9"},{"key":"bibr7-0300060520985679","first-page":"CD003641","volume":"8","author":"Colquitt JL","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr8-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002670"},{"key":"bibr9-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167907"},{"key":"bibr10-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200212000-00061"},{"key":"bibr11-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200611000-00007"},{"key":"bibr12-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.08.022"},{"key":"bibr13-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6329"},{"key":"bibr14-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1992.tb03570.x"},{"key":"bibr15-0300060520985679","first-page":"266","volume":"41","author":"Bom A","year":"2002","journal-title":"Angew Chem Int Ed Engl"},{"key":"bibr16-0300060520985679","first-page":"CD012763","volume":"8","author":"Hristovska AM","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr17-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182580409"},{"key":"bibr18-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer330"},{"key":"bibr19-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1998.53s111.x"},{"key":"bibr20-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31818a3fee"},{"key":"bibr21-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01352.x"},{"key":"bibr22-0300060520985679","first-page":"138","volume":"83","author":"Abd El-Rahman AM","year":"2017","journal-title":"Minerva Anestesiol"},{"key":"bibr23-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjan.2017.10.010"},{"key":"bibr24-0300060520985679","first-page":"389782","volume":"2013","author":"Sanfilippo M","year":"2013","journal-title":"Anesthesiology Res Pract"},{"key":"bibr25-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13344"},{"key":"bibr26-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000305"},{"key":"bibr27-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes137"},{"key":"bibr28-0300060520985679","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2010.06611.x"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520985679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0300060520985679","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0300060520985679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:47:01Z","timestamp":1777459621000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0300060520985679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/0300060520985679"],"URL":"https:\/\/doi.org\/10.1177\/0300060520985679","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"0300060520985679"}}