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Although the persistence of PSH increases the risk of several adverse events and worsens the prognosis, pharmacological treatments for PSH have not yet been clearly established. We report the valuable case of a 60-year-old man who developed PSH following hypoxic encephalopathy, which was effectively treated with a combination therapy of gabapentin and guanfacine. The present case suggests that combination therapy with gabapentin and guanfacine may be a therapeutic option for PSH.<\/jats:p>","DOI":"10.1177\/03000605211009721","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T14:15:17Z","timestamp":1619446517000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of combination therapy with gabapentin and guanfacine for paroxysmal sympathetic hyperactivity following hypoxic encephalopathy: a case report"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-804X","authenticated-orcid":false,"given":"Takafumi","family":"Miyoshi","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Itami City Hospital, Itami-shi, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikaru","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Nursing, Itami City Hospital, Itami-shi, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Noborio","sequence":"additional","affiliation":[{"name":"Department of Nursing, Itami City Hospital, Itami-shi, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Kimoto","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Itami City Hospital, Itami-shi, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Nakaharu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Itami City Hospital, Itami-shi, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsaku","family":"Shimamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Itami City Hospital, Itami-shi, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"bibr1-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2017.10.012"},{"key":"bibr2-03000605211009721","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00081"},{"key":"bibr3-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30259-4"},{"key":"bibr4-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2013.3301"},{"key":"bibr5-03000605211009721","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2020.01021"},{"key":"bibr6-03000605211009721","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn-000793"},{"key":"bibr7-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.15010055"},{"key":"bibr8-03000605211009721","first-page":"45","volume":"85","author":"Arnsten AF","year":"2012","journal-title":"Yale J Biol Med"},{"key":"bibr9-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2014.10.002"},{"key":"bibr10-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4087"},{"key":"bibr11-03000605211009721","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19m12979"},{"key":"bibr12-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00048-2"},{"key":"bibr13-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00127-4"},{"key":"bibr14-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22066"},{"key":"bibr15-03000605211009721","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.015"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211009721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605211009721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211009721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:57Z","timestamp":1777459737000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605211009721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1177\/03000605211009721"],"URL":"https:\/\/doi.org\/10.1177\/03000605211009721","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"article-number":"03000605211009721"}}