{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:17:10Z","timestamp":1792552630404,"version":"4.5.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Preterm infants receive long-term parenteral nutrition (PN) for gastrointestinal immaturity. This study aimed to determine if mixed lipid emulsions containing fish oil decrease the incidence of PN-associated cholestasis by reducing oxidative stress and providing an anti-inflammatory effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study enrolled 399 very low birth weight premature infants (gestational age \u226432 weeks) between January 2009 and November 2017 at a single neonatal intensive care unit. Preterm infants received total PN with either mixed lipid emulsion including fish oil (SMOFlipid\u00ae, n\u2009=\u2009195) or soybean oil-based lipid emulsion (Lipovenoes\u00ae, n\u2009=\u2009204) for at least 7 days. We compared the outcomes of PN-associated cholestasis, comorbidities, and mortality between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of PN-associated cholestasis was significantly lower in the SMOFlipid group than in the Lipovenoes group. The duration to full feeding days was significantly shorter in the SMOFlipid group compared with the Lipovenoes group. Relevant complications, such as severe retinopathy of prematurity and bronchopulmonary dysplasia, were also significantly reduced in the SMOFlipid group compared with the Lipovenoes group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In premature infants, PN with fish oil-based lipid emulsions is associated with a lower incidence of PN-associated cholestasis compared with soybean oil-based lipid emulsions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605211011805","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T09:11:23Z","timestamp":1620897083000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Parenteral nutrition with fish oil-based lipid emulsion reduces the risk of cholestasis in preterm infants"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-4347","authenticated-orcid":false,"given":"Yi-Ling","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Changhua Christian Children\u2019s Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih-Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Changhua Christian Children\u2019s Hospital, Changhua, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lon-Yen","family":"Tsao","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Changhua Christian Children\u2019s Hospital, Changhua, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Neng","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Changhua Christian Children\u2019s Hospital, Changhua, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Changhua Christian Children\u2019s Hospital, Changhua, Taiwan"},{"name":"School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-5300","authenticated-orcid":false,"given":"Chien-Chou","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Changhua Christian Children\u2019s Hospital, Changhua, Taiwan"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"},{"name":"School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"bibr1-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000181841.07090.f4"},{"key":"bibr2-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181de210c"},{"key":"bibr3-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e3283394879"},{"key":"bibr4-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000174"},{"key":"bibr5-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111424411"},{"key":"bibr6-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1177\/0148607106030004351"},{"key":"bibr7-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000222118.76536.ad"},{"key":"bibr8-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.01.004"},{"key":"bibr9-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32802bf787"},{"key":"bibr10-03000605211011805","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060776"},{"key":"bibr11-03000605211011805","author":"Hsiao CC","year":"2018","journal-title":"Clin Nutr"},{"key":"bibr12-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.e177"},{"key":"bibr13-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.4.855"},{"key":"bibr14-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.1.256S"},{"key":"bibr15-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117721907"},{"key":"bibr16-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-009-9197-2"},{"key":"bibr17-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3940241"},{"key":"bibr18-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1417-7"},{"key":"bibr19-03000605211011805","doi-asserted-by":"publisher","DOI":"10.3390\/nu7095334"},{"key":"bibr20-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-019-1610-7"},{"key":"bibr21-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63309-9"},{"key":"bibr22-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-015-0178-7"},{"key":"bibr23-03000605211011805","first-page":"838","volume":"45","author":"Tang QY","year":"2007","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"bibr24-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00232-3"},{"key":"bibr25-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114481"},{"key":"bibr26-03000605211011805","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.141688"},{"key":"bibr27-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2016.01.012"},{"key":"bibr28-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-14-9"},{"key":"bibr29-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0888-7"},{"key":"bibr30-03000605211011805","doi-asserted-by":"publisher","DOI":"10.20960\/nh.882"},{"key":"bibr31-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.2.282"},{"key":"bibr32-03000605211011805","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27951"},{"key":"bibr33-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1159\/000080461"},{"key":"bibr34-03000605211011805","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2434"},{"key":"bibr35-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-006-0986-z"},{"key":"bibr36-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2009.05.020"},{"key":"bibr37-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199902000-00008"},{"key":"bibr38-03000605211011805","author":"Lavallee CM","year":"2018","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"bibr39-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(02)01009-2"},{"key":"bibr40-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200005000-00039"},{"key":"bibr41-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.11.012"},{"key":"bibr42-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-016-0611-0"},{"key":"bibr43-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13487"},{"key":"bibr44-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001571"},{"key":"bibr45-03000605211011805","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7110160"},{"key":"bibr46-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1177\/0148607117721907"},{"key":"bibr47-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2010.04.009"},{"key":"bibr48-03000605211011805","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2017.04.004"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211011805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605211011805","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211011805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:06Z","timestamp":1777459746000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605211011805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/03000605211011805"],"URL":"https:\/\/doi.org\/10.1177\/03000605211011805","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"article-number":"03000605211011805"}}