{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:56:52Z","timestamp":1793213812787,"version":"4.5.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Prognostic indicators in acute coronary syndrome (ACS) would aid in decision-making and identifying high-risk patients. The systemic immune-inflammation index (SII) has good prognostic value in many diseases; however, its use has not been reported for ACS. We aimed to determine the associations between the SII and outcomes in patients with ACS, with adjustment for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, we used the MIMIC-III (Multiparameter Intelligent Monitoring in Intensive Care) database and the eICU Collaborative Research Database. The primary outcome was 30-day mortality. Cox regression analysis was performed to determine the relationship between the SII and patient outcomes, and we conducted subgroup analysis and smooth curve fitting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 4699 patients with ACS: 1741 women and 2949 men, mean age 82.8\u00b129.7 years, and mean SII 72.58\u00b112.9. For 30-day all-cause mortality, the unadjusted hazard ratio (HR) (95% confidence interval [CI]) of SII &lt;69.4 and SII &gt;88.8 were 1.25 (1.04, 1.50) and 1.38 (1.15, 1.65), respectively. With SII &gt;88.8, this association remained significant after adjustment for numerous potential confounders: HR 1.27 (1.06, 1.52). A similar relationship was observed for 90-day and 1-year all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SII is a promising prognostic indicator for unselected patients with ACS. This finding needs to be confirmed in prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605211016274","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T02:42:37Z","timestamp":1621996957000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":39,"title":["Systemic immune-inflammation index as a promising predictor of mortality in patients with acute coronary syndrome: a real-world study"],"prefix":"10.1177","volume":"49","author":[{"given":"Gaofan","family":"Su","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-5733","authenticated-orcid":false,"given":"Binbin","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"bibr1-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31012-1"},{"key":"bibr2-03000605211016274","first-page":"0","volume":"148","author":"Petersen JL","journal-title":"Am Heart J"},{"key":"bibr3-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-014-0435-z"},{"key":"bibr4-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328350a487"},{"key":"bibr5-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.174557"},{"key":"bibr6-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02969-8"},{"key":"bibr7-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"bibr8-03000605211016274","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S223419"},{"key":"bibr9-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0442"},{"key":"bibr10-03000605211016274","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00376"},{"key":"bibr11-03000605211016274","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S190006"},{"key":"bibr12-03000605211016274","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2019-0303"},{"key":"bibr13-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.08.006"},{"key":"bibr14-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.35"},{"key":"bibr15-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"bibr16-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.178"},{"key":"bibr17-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.071"},{"key":"bibr18-03000605211016274","doi-asserted-by":"crossref","unstructured":"Nahler G. ICD-9 code. 2009; 28(10): 88.","DOI":"10.1007\/978-3-211-89836-9_658"},{"key":"bibr19-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0000000000000735"},{"key":"bibr20-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200002000-00023"},{"key":"bibr21-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000178178.02574.AB"},{"key":"bibr22-03000605211016274","volume-title":"Glasgow Coma Scale (GCS)","author":"Frcpc DJDM.","year":"1989"},{"key":"bibr23-03000605211016274","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-12-3-169"},{"key":"bibr24-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.03.1616"},{"key":"bibr25-03000605211016274","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.09.02"},{"key":"bibr26-03000605211016274","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02325-9"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211016274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605211016274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211016274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:19Z","timestamp":1777459759000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605211016274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/03000605211016274"],"URL":"https:\/\/doi.org\/10.1177\/03000605211016274","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"article-number":"03000605211016274"}}