{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:25:08Z","timestamp":1785533108522,"version":"3.56.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>At our institution, patients with platelet refractoriness (of any etiology) are sometimes switched from apheresis platelets to pooled platelets before human leukocyte antigen (HLA)-matched units become available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design and methods<\/jats:title>\n                    <jats:p>Seven patients were analyzed. Platelet counts were available from 57 single-unit transfusions (26 pooled, 31 apheresis). A mixed linear effects model was used and significance was determined using a likelihood ratio test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When analyzed as the only fixed effect in the model, the use of pooled versus single-donor units and time from transfusion to post-transfusion blood sampling each showed a significant effect on platelet count increments. A mixed linear effect model including both factors showed that transfusing a pooled unit correlated with a 4500\u00b12000\/\u00b5L greater platelet count increment compared with a single-donor unit, and an increase in time from transfusion to post-transfusion blood sampling lowered the platelet count increment by 300\u00b1100\/\u00b5L per hour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A small but potentially clinically relevant benefit was observed in transfusing pooled random-donor platelets compared with single-donor units for patients with platelet refractoriness (of any etiology).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605211016748","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T05:44:25Z","timestamp":1621489465000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Pooled platelet concentrates provide a small benefit over single-donor platelets for patients with platelet refractoriness of any etiology"],"prefix":"10.1177","volume":"49","author":[{"given":"Ying-Hsia","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-1927","authenticated-orcid":false,"given":"William Nicholas","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Nawrot","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Raife","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"bibr1-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050280"},{"key":"bibr2-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.00011.x-i1"},{"key":"bibr3-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2724"},{"key":"bibr4-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13597"},{"key":"bibr5-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1936.x"},{"key":"bibr6-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30790385520.x"},{"key":"bibr7-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03387.x"},{"key":"bibr8-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12739"},{"key":"bibr9-03000605211016748","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i01"},{"key":"bibr10-03000605211016748","unstructured":"Bates D, Chambers J, Dalgaard P, et\u00a0al. 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Linear models and linear mixed effects models in R with linguistic applications. arXiv: 1308.5499 2013. https:\/\/scholar.google.com\/scholar?cluster=1085590172930 7493922&hl=en&as_sdt=5,50&sciodt=0,50"},{"key":"bibr12-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.1997.d01-73.x"},{"key":"bibr13-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705751"},{"key":"bibr14-03000605211016748","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15333"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211016748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605211016748","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211016748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:49:22Z","timestamp":1777459762000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605211016748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1177\/03000605211016748"],"URL":"https:\/\/doi.org\/10.1177\/03000605211016748","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]},"article-number":"03000605211016748"}}