{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:18:10Z","timestamp":1784715490606,"version":"3.55.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the clinical efficacy and safety of dexmedetomidine and propofol in patients who underwent gastrointestinal endoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant studies comparing dexmedetomidine and propofol among patients who underwent gastrointestinal endoscopy were retrieved from databases such as PubMed, Embase, and Cochrane Library.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven relevant studies (dexmedetomidine group, n\u2009=\u2009238; propofol group, n\u2009=\u2009239) met the inclusion criteria. There were no significant differences in the induction time (weighted mean difference [WMD]\u2009=\u20093.46, 95% confidence interval [CI]\u2009=\u2009\u22120.95\u20137.88, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200999%) and recovery time (WMD\u2009=\u20092.74, 95% CI\u2009=\u2009\u22122.72\u20138.19, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200998%). Subgroup analysis revealed no significant differences in the risks of hypotension (risk ratio [RR]\u2009=\u20090.56, 95% CI\u2009=\u20090.25\u20131.22) and nausea and vomiting (RR\u2009=\u20091.00, 95% CI\u2009=\u20090.46\u20132.22) between the drugs, whereas dexmedetomidine carried a lower risk of hypoxia (RR\u2009=\u20090.26, 95% CI\u2009=\u20090.11\u20130.63) and higher risk of bradycardia (RR\u2009=\u20093.01, 95% CI\u2009=\u20091.38\u20136.54).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dexmedetomidine had similar efficacy and safety profiles as propofol in patients undergoing gastrointestinal endoscopy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605211032786","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T01:08:20Z","timestamp":1627261700000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of clinical efficacy and safety between dexmedetomidine and propofol among patients undergoing gastrointestinal endoscopy: a meta-analysis"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0147-9928","authenticated-orcid":false,"given":"Weihua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Tianjin First Center Hospital, Tianjin, P.R. 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