{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:35:35Z","timestamp":1788446135093,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971652"],"award-info":[{"award-number":["81971652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>\n                    Kikuchi\u2013Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting inflammatory disorder of unknown etiology and pathogenesis. This report presents a rare case involving a man with\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorodeoxyglucose positron emission tomography\/computed tomography (FDG PET\/CT) hypermetabolism caused by KFD mimicking malignant lymphoma. The PET\/CT maximum intensity projection showed multiple hypermetabolic lymphadenopathies and homogeneous FDG uptake in the bone marrow and spleen. Malignant lymphoma was initially suspected. The patient then underwent excision biopsy of one enlarged right cervical lymph node that was selected because it showed the highest FDG uptake in PET\/CT, and examination of this biopsy specimen confirmed the diagnosis of KFD. PET\/CT is useful for assessing the general condition of patients and can help to select lymph nodes for excision biopsy based on the highest FDG uptake. However, KFD can predispose to localized FDG uptake and limit the specificity of PET\/CT by mimicking malignancy. Thus, positive results of PET\/CT should be interpreted with caution.\n                  <\/jats:p>","DOI":"10.1177\/03000605211032859","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T03:15:14Z","timestamp":1627701314000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Positron emission tomography\/computed tomography hypermetabolism of Kikuchi\u2013Fujimoto disease mimicking malignant lymphoma: a case report and literature review"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-9770","authenticated-orcid":false,"given":"Shu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, The First Hospital of China Medical University, The First Hospital of China Medical University, Shenyang, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Hospital of China Medical University, The First Hospital of China Medical University, Shenyang, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuena","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Hospital of China Medical University, The First Hospital of China Medical University, Shenyang, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The First Hospital of China Medical University, The First Hospital of China Medical University, Shenyang, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"bibr1-03000605211032859","doi-asserted-by":"publisher","DOI":"10.1309\/YF081L4TKYWVYVPQ"},{"key":"bibr2-03000605211032859","doi-asserted-by":"publisher","DOI":"10.5858\/134.2.289"},{"key":"bibr3-03000605211032859","first-page":"120","volume":"108","author":"Pepe F","year":"2016","journal-title":"Pathologica"},{"key":"bibr4-03000605211032859","unstructured":"Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes: a clinicopathological study. Acta Hematol Jpn 1972;  35: 379\u2013380."},{"key":"bibr5-03000605211032859","unstructured":"Fujimoto Y, Kozima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis: a new clinicopathologic entity. 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