{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:54:31Z","timestamp":1780487671690,"version":"3.54.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Science and Technology Development Incubation Fund Project of Shaanxi Provincial People's Hospital","award":["2019YXQ-08"],"award-info":[{"award-number":["2019YXQ-08"]}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"crossref","award":["2020JQ-939"],"award-info":[{"award-number":["2020JQ-939"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the predictive value of hyperhomocysteinaemia (HHcy) for obstructive coronary artery disease (CAD) in an Asian population in northern China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled patients at their first cardiac assessment and assigned them to an obstructive CAD group or a non-obstructive CAD group according to the coronary angiography results. HHcy was defined as a homocysteine (Hcy) level\u2009&gt;\u200915\u2009\u00b5mol\/l.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study enrolled 2987 participants: 1172 in the non-obstructive CAD group and 1815 in the obstructive CAD group. Hcy level in the obstructive CAD group was significantly higher than in the non-obstructive CAD group. The proportion of patients with HHcy in the obstructive CAD group was significantly greater than in the non-obstructive CAD group. Multivariate logistic regression analysis demonstrated that HHcy was independently correlated with obstructive CAD in both young (aged \u2264 55 years) and old patients (aged\u2009&gt;\u200955 years). HHcy showed a higher sensitivity (93.1%), specificity (86.1%) and accuracy (90.0%) for obstructive CAD. The odds ratio for HHcy was 84.2. The Kappa value (0.8) showed substantial agreement between obstructive CAD and HHcy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HHcy was associated with obstructive CAD and may be a potentially independent risk factor for obstructive CAD with good predictive value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605211033495","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T12:02:56Z","timestamp":1626955376000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of the association and predictive value of hyperhomocysteinaemia for obstructive coronary artery disease"],"prefix":"10.1177","volume":"49","author":[{"given":"Hao-Yu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shaanxi Provincial People's Hospital, Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Jiao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Xi\u2019an Children\u2019s Hospital, Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-5489","authenticated-orcid":false,"given":"Yi-Wei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology, Shaanxi Provincial People's Hospital, Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yu","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shaanxi Provincial People's Hospital, Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Hua","family":"You","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shaanxi Provincial People's Hospital, Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Wei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shaanxi Provincial People's Hospital, Xi\u2019an, Shaanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"bibr1-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28350"},{"key":"bibr2-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-2517-9_1"},{"key":"bibr3-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-019-4835-2"},{"key":"bibr4-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32203-7"},{"key":"bibr5-03000605211033495","doi-asserted-by":"publisher","DOI":"10.3109\/13685538.2011.654369"},{"key":"bibr6-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1161\/hc0302.102575"},{"key":"bibr7-03000605211033495","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S216180"},{"key":"bibr8-03000605211033495","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2016(04)11"},{"key":"bibr9-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-013-0022-3"},{"key":"bibr10-03000605211033495","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180313105949"},{"key":"bibr11-03000605211033495","first-page":"22","volume":"66","author":"Bahulikar A","year":"2018","journal-title":"J Assoc Physicians India"},{"key":"bibr12-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00003.2018"},{"key":"bibr13-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c150021"},{"key":"bibr14-03000605211033495","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED.169.4.325"},{"key":"bibr15-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1818"},{"key":"bibr16-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2018.1497974"},{"key":"bibr17-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-018-1016-4"},{"key":"bibr18-03000605211033495","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040867"},{"key":"bibr19-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1007\/BF02912875"},{"key":"bibr20-03000605211033495","first-page":"1229","volume":"50","author":"Snehalatha C","year":"2002","journal-title":"J Assoc Physicians India"},{"key":"bibr21-03000605211033495","first-page":"44","volume":"53","author":"Deepa R","year":"2001","journal-title":"Indian Heart J"},{"key":"bibr22-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2016.09.005"},{"key":"bibr23-03000605211033495","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr24-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-013-3761-y"},{"key":"bibr25-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2019.03.012"},{"key":"bibr26-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/625939"},{"key":"bibr27-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpx207"},{"key":"bibr28-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1055\/a-1018-9078"},{"key":"bibr29-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02409-8"},{"key":"bibr30-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-013-0373-5"},{"key":"bibr31-03000605211033495","first-page":"111","volume":"56","author":"McCully KS.","year":"1969","journal-title":"Am J Pathol"},{"key":"bibr32-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32834741ff"},{"key":"bibr33-03000605211033495","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4103\/njcp.njcp_120_19","volume":"22","author":"Wang F","year":"2019","journal-title":"Niger J Clin Pract"},{"key":"bibr34-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1086\/301836"},{"key":"bibr35-03000605211033495","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2019.10.08"},{"key":"bibr36-03000605211033495","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001177"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211033495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605211033495","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211033495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:07Z","timestamp":1777459687000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605211033495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/03000605211033495"],"URL":"https:\/\/doi.org\/10.1177\/03000605211033495","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]},"article-number":"03000605211033495"}}