{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T18:29:01Z","timestamp":1788114541682,"version":"build-2803163510"},"reference-count":9,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Malignant hyperthermia (MH) is a potentially fatal hypermetabolic syndrome that occurs when susceptible individuals are exposed to triggering agents. Variability in the order and time of occurrence of symptoms often makes clinical diagnosis difficult. A late diagnosis or misdiagnosis of delayed-onset MH may lead to fatal complications. We herein report a case of delayed-onset MH in the postoperative recovery room. A 77-year-old man awoke from anesthesia and was transferred to the recovery room. Ten minutes after his arrival, his mental status became stuporous and he developed masseter muscle rigidity, hyperventilation, and a body temperature of 39.8\u00b0C. The patient was suspected to have MH, and 60\u2009mg of dantrolene sodium (1\u2009mg\/kg) was administered via intravenous drip with symptomatic treatment. Within 10 minutes of dantrolene administration, the patient\u2019s clinical signs subsided. This case report demonstrates that rapid diagnosis and treatment are crucial to ensure a good prognosis for patients with MH. A high level of suspicion based on clinical symptoms and early administration of therapeutic drugs such as dantrolene will also improve the clinical course. Therefore, suspicion and prompt diagnosis are absolutely essential. This case report emphasizes the importance of continuous education in the diagnosis and treatment of MH.<\/jats:p>","DOI":"10.1177\/03000605211044201","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T14:05:05Z","timestamp":1632924305000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Delayed-onset malignant hyperthermia in the postanesthetic care unit: a case report"],"prefix":"10.1177","volume":"49","author":[{"given":"Ji Young","family":"Min","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-8724","authenticated-orcid":false,"given":"Mee Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"bibr1-03000605211044201","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2018.05.016"},{"key":"bibr2-03000605211044201","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2018.10.002"},{"key":"bibr3-03000605211044201","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318200197d"},{"key":"bibr4-03000605211044201","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq243"},{"key":"bibr5-03000605211044201","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2013.0603"},{"key":"bibr6-03000605211044201","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer132"},{"key":"bibr7-03000605211044201","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c6b9b2"},{"key":"bibr8-03000605211044201","doi-asserted-by":"publisher","DOI":"10.1017\/S0195941700061749"},{"key":"bibr9-03000605211044201","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0310-1"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211044201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605211044201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211044201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:48:35Z","timestamp":1777459715000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605211044201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1177\/03000605211044201"],"URL":"https:\/\/doi.org\/10.1177\/03000605211044201","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"article-number":"03000605211044201"}}