{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:40:21Z","timestamp":1788795621599,"version":"build-2803163510"},"reference-count":43,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the clinical and laboratory predictors of venous thromboembolism (VTE) in patients with sickle cell anaemia (SCA) and its relationship to morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case\u2013control study analysed data from patients with SCA that experienced VTE compared with matched control patients with SCA but no VTE (2:1 ratio).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 102 patients with SCA were enrolled (68 cases with VTE and 34 controls). Amongst the 68 cases (median age, 29.5 years), 26 (38.2%) presented with isolated pulmonary embolism (PE). A higher prevalence of splenectomy (73.5% versus 35.3%) was observed in the cases compared with the controls. A significantly higher prevalence of central venous catheter (CVC) insertion (42.6% versus 8.8%) was observed in the cases compared with the controls. High white blood cell counts, serum lactic dehydrogenase (LDH), bilirubin and C-reactive protein (CRP) and low haemoglobin (Hb) and HbF were significant risk factors for VTE. Forty-two cases (61.8%) developed acute chest syndrome, 10 (14.7%) had a stroke and seven (10.3%) died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VTE in patients with SCA has a high impact on morbidity and mortality. PE was the leading presentation of VTE, with CVC insertion, high LDH, bilirubin, CRP and white blood cell counts along with low Hb and HbF constituting other significant risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605211055385","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T13:44:18Z","timestamp":1638452658000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia \u2013 lessons learned for prophylaxis"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-5748","authenticated-orcid":false,"given":"Salam","family":"Alkindi","sequence":"first","affiliation":[{"name":"Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman"},{"name":"College of Medicine & Health Sciences, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwaar R","family":"Al-Ghadani","sequence":"additional","affiliation":[{"name":"Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah R","family":"Al-Zeheimi","sequence":"additional","affiliation":[{"name":"Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said Y","family":"Alkindi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Al-Nahdha Hospital, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa","family":"Fawaz","sequence":"additional","affiliation":[{"name":"Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman"},{"name":"College of Medicine & Health Sciences, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir K","family":"Ballas","sequence":"additional","affiliation":[{"name":"Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil V","family":"Pathare","sequence":"additional","affiliation":[{"name":"Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"bibr1-03000605211055385","doi-asserted-by":"publisher","DOI":"10.17265\/2159-5313\/2016.09.003"},{"key":"bibr2-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"bibr3-03000605211055385","doi-asserted-by":"publisher","DOI":"10.26719\/2001.7.6.1004"},{"key":"bibr4-03000605211055385","doi-asserted-by":"publisher","DOI":"10.3109\/03630261003677213"},{"key":"bibr5-03000605211055385","unstructured":"Bender MA. Sickle Cell Disease. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K and Amemiya A (eds)\n                      Gene Reviews\n                      \u00ae. Seattle (WA): University of Washington, Seattle; 1993\u20132021. 2003 Sep 15 [updated 28 Jan 2021]."},{"key":"bibr6-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709113371107"},{"key":"bibr7-03000605211055385","first-page":"532","volume":"134","author":"Odi\u00e8vre MH","year":"2011","journal-title":"Indian J Med Res"},{"key":"bibr8-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89741"},{"key":"bibr9-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-498311"},{"key":"bibr10-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1080\/10739680802279394"},{"key":"bibr11-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-2082CI"},{"key":"bibr12-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.79.933.384"},{"key":"bibr13-03000605211055385","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2014.18.30.4043"},{"key":"bibr14-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.11.2104101"},{"key":"bibr15-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017012336"},{"key":"bibr16-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-013-0895-y"},{"key":"bibr17-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2531-8"},{"key":"bibr18-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.08.015"},{"key":"bibr19-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14655"},{"key":"bibr20-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12744"},{"key":"bibr21-03000605211055385","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"bibr22-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.01.073"},{"key":"bibr23-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184879"},{"key":"bibr24-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0378-3"},{"key":"bibr25-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24408"},{"key":"bibr26-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V120.21.3222.3222"},{"key":"bibr27-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.128059"},{"key":"bibr28-03000605211055385","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.211466"},{"key":"bibr29-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2007.1.74"},{"key":"bibr30-03000605211055385","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02569"},{"key":"bibr31-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2011.10.004"},{"key":"bibr32-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.09.037"},{"key":"bibr33-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(15)50442-8"},{"key":"bibr34-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2288"},{"key":"bibr35-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30193-9"},{"key":"bibr36-03000605211055385","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04861.x"},{"key":"bibr37-03000605211055385","unstructured":"Wild BJ,  andBain BJ. 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