{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:12:53Z","timestamp":1787505173812,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Research projects of the Committee of Science and Technology, Chaoyang District, Beijing","award":["CYSF-1835"],"award-info":[{"award-number":["CYSF-1835"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to analyze the changes in serum inflammatory cytokines and anti-inflammatory cytokines in patients with gouty arthritis (GA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data and serum samples in patients with gouty arthritis and those in healthy volunteers were collected in China-Japan Friendship Hospital from July 2018 to January 2019. Serum cytokine concentrations in patients with GA and volunteers (controls) were determined by a chemiluminescence method. The differences in cytokine concentrations were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Concentrations of serum interleukin-1 beta (IL-1\u00df), tumor necrosis factor-alpha (TNF-\u03b1), IL-6, IL-8, and IL-4 were significantly higher in patients with acute GA than in controls. Serum concentrations of IL-1\u00df, TNF-\u03b1, IL-6, IL-8, and immunoglobulin E in patients with remission of GA were significantly lower, whereas concentrations of IL-10 and interferon-\u03b3 were significantly higher, compared with those in patients with acute GA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study shows that serum concentrations of IL-1\u00df, TNF-\u03b1, IL-6, IL-8, and IL-4 are significantly elevated in patients with GA, and may be involved in the pathogenesis of GA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605211055618","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T02:11:07Z","timestamp":1636769467000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Profile of serum cytokine concentrations in patients with gouty arthritis"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3488-605X","authenticated-orcid":false,"given":"Tie","family":"Zhang","sequence":"first","affiliation":[{"name":"Laboratory of China-Japan Friendship Hospital, China-Japan Friendship Hospital, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of China-Japan Friendship Hospital, China-Japan Friendship Hospital, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Laboratory of China-Japan Friendship Hospital, China-Japan Friendship Hospital, Beijing, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrine, China-Japan Friendship Hospital, China-Japan Friendship Hospital, Beijing, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Echocadiography, The First Hospital of JiLin University, Changchun, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"bibr1-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00346-9"},{"key":"bibr2-03000605211055618","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136678"},{"key":"bibr3-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1420167"},{"key":"bibr4-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001124"},{"key":"bibr5-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-1201ufm"},{"key":"bibr6-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.143"},{"key":"bibr7-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.32"},{"key":"bibr8-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.166"},{"key":"bibr9-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208237"},{"key":"bibr10-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.126"},{"key":"bibr11-03000605211055618","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"},{"key":"bibr12-03000605211055618","first-page":"56","volume":"63","author":"Saigal R","year":"2015","journal-title":"J Assoc Physicians India"},{"key":"bibr13-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0115-y"},{"key":"bibr14-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12839"},{"key":"bibr15-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000143"},{"key":"bibr16-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.02.003"},{"key":"bibr17-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/264859"},{"key":"bibr18-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp241"},{"key":"bibr19-03000605211055618","first-page":"243","volume":"69","author":"Ling X","year":"2014","journal-title":"Pharmazie"},{"key":"bibr20-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1177\/1535370219830665"},{"key":"bibr21-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6548-9_2"},{"key":"bibr22-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22348"},{"key":"bibr23-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.02.026"},{"key":"bibr24-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88876"},{"key":"bibr25-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.03.003"},{"key":"bibr26-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12160"},{"key":"bibr27-03000605211055618","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.07.009"}],"container-title":["Journal of International Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211055618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03000605211055618","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03000605211055618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:47:25Z","timestamp":1777459645000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03000605211055618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1177\/03000605211055618"],"URL":"https:\/\/doi.org\/10.1177\/03000605211055618","relation":{},"ISSN":["0300-0605","1473-2300"],"issn-type":[{"value":"0300-0605","type":"print"},{"value":"1473-2300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11]]},"article-number":"03000605211055618"}}