{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T07:16:30Z","timestamp":1794640590577,"version":"4.9.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Int Med Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To perform a meta-analysis of randomized controlled trials to evaluate the efficacy of vitamin D supplementation on thyroid autoimmunity markers in Hashimoto\u2019s thyroiditis (HT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This meta-analysis included randomized controlled clinical trials identified by a systematic search of electronic databases (PubMed\u00ae, MEDLINE\u00ae, EMBASE, The Cochrane Library, China National Knowledge Infrastructure) from inception to August 2020. All studies included patients with HT that received vitamin D supplementation irrespective of the doses administered or the duration of treatment. The primary and secondary outcome measures were thyroid peroxidase antibody (TPOAb) and\/or thyroglobulin antibody (TGAb) titres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight studies ( n\u2009=\u2009652) were included. There was significant heterogeneity between the studies. Using a random-effect model, vitamin D supplementation reduced TPOAb titre (standardized mean difference [SMD]: \u20131.11; 95% confidence interval [CI]: 1\u20131.92, \u20130.29) and TGAb titre (SMD: \u20131.12; 95% CI: \u20131.96, \u20130.28). A subgroup analysis demonstrated that vitamin D supplementation for &gt;3 months resulted in a decrease in TPOAb titre (SMD: \u20131.66, 95% CI: \u20132.91, \u20130.41) but treatment \u22643 months was ineffective. Treatment with vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      decreased TPOAb titre (SMD: \u20131.48; 95% CI: \u20132.53, \u20130.42) whereas vitamin D did not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data suggest that vitamin D reduces autoantibody titre in patients with HT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03000605211060675","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T17:13:52Z","timestamp":1638810832000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Effects of vitamin D on thyroid autoimmunity markers in Hashimoto\u2019s thyroiditis: systematic review and meta-analysis"],"prefix":"10.1177","volume":"49","author":[{"given":"Jingwen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9614-2964","authenticated-orcid":false,"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"bibr1-03000605211060675","first-page":"205","volume":"1","author":"Lorini R","year":"2003","journal-title":"Pediatr Endocrinol 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